Addiction Scientific Publications

Latest publication 07/23/2022

Neuromuscular mechanisms of weakness in a mouse model of chronic alcoholic myopa

Weakness is a common clinical symptom reported in individuals with chronic alcohol use disorder. However, it remains unclear whether low strength...

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    [title] => Neuromuscular mechanisms of weakness in a mouse model of chronic alcoholic myopa
    [paragraph] => Neuromuscular mechanisms of weakness in a mouse model of chronic alcoholic myopathy
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Authors
SE Moser, AM Brown, BC Clark

 Lab
Department of Biomedical Sciences, Ohio University, Athens, Ohio, USA
Journal
Alcoholism: Clinical and Experimental Research
Abstract
Weakness is a common clinical symptom reported in individuals with chronic alcohol use disorder. However, it remains unclear whether low strength in these individuals is directly related to excessive ethanol intake, other deleterious factors (lifestyle, environment, genetics, etc.), or a combination of both. Therefore, we examined whether (and how) ethanol reduces the muscle’s force-producing capacity using a controlled in vivo preclinical mouse model of excessive ethanol intake.
BIOSEB Instruments Used
Grip strength test (BIO-GS3)
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An easy way to objectively quantify the muscular strength of mice and rats, and to assess the effect of drugs, toxins, muscular (i.e. myopathy) and neurodegenerative diseases on muscular degeneration. It is widely used in conjunction with the ROTAROD motor coordination test: a normally coordinated rodent will show a decreased latency to fall off the rotating rod if its muscular strength is low. The Grip Strength Test is a must for your research on activity, motor control & coordination, and is particularly well suited for studies on Parkinson's & Huntington's disease.
New features GS4 - 2023: Color display with permanent backlight screen for easier reading, reset by footswitch, Improved battery time, Larger data memory of 500 values, Animal counter, USB port (charging/data transfer)

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