Publications

Latest publication 04/01/2008

Cutaneous Amitriptyline in Human Volunteers- Differential Effects on the Compone

Background : Amitriptyline is effective in relieving neuropathic pain. Its site of action is thought to be supraspinal and spinal, but a...

Array
(
    [id_prestablog_news] => 1368
    [id_shop] => 1
    [date] => 2008-04-01 00:00:00
    [date_modification] => 2024-02-09 14:15:12
    [langues] => ["1","2"]
    [actif] => 1
    [slide] => 0
    [url_redirect] => 
    [average_rating] => 
    [number_rating] => 
    [author_id] => 1
    [featured] => 0
    [prim_key] => 2915
    [id_lang] => 1
    [title] => Cutaneous Amitriptyline in Human Volunteers- Differential Effects on the Compone
    [paragraph] => Cutaneous Amitriptyline in Human Volunteers- Differential Effects on the Components of Sensory Information
    [content] => 
Authors
C Duale, J Daveau, JM Cardot et al

 Lab
Centre Hospitalier Universitaire (CHU) Clermont-Ferrand, Service d'Anesthesie-Reanimation, Hopital Gabriel-Montpied, France
Journal
Anesthesiology
Abstract
Background: Amitriptyline is effective in relieving neuropathic pain. Its site of action is thought to be supraspinal and spinal, but a peripheral effect on fibers is also suggested/
Methods This double-blind study examined the effects of transcutaneous amitriptyline diluted in hydroalcoholic solution in healthy young male volunteers. Six treatments were randomly applied on different areas of the skin of the back: amitriptyline at 0 (vehicle), 25, 50, and 100 mm; saline (control); and lidocaine-prilocaine cream as a positive control. Up to 24 h after application, mechanical thresholds for touch and nociception, and thermal thresholds for cold, warm, and heat sensation were recorded for each area. Blood samples were collected to assess plasma levels of amitriptyline. A late recording of the tactile thresholds was performed 1 and 3 weeks after the treatment session.
Results The thresholds for all sensations did not differ between the vehicle and saline. Lidocaine-prilocaine cream displayed a short-lasting anesthetic effect for all sensations, although this was not significant for warm sensation. Amitriptyline, at the three concentrations studied, induced a mild and short-lasting increase of the tactile and mechanical nociceptive thresholds. It significantly decreased cold thresholds (down to 21.8 degrees C, P = 0.01 vs. 27.5 degrees C for control) and heat thresholds (down to 40.1 degrees C, P = 0.004 vs. 43.4 degrees C for control). These two effects were no longer significant after the fourth hour of observation. Amitriptyline did not change warm thresholds. There was no apparent systemic absorption effect of the drug.
Conclusion It is hypothesized that amitriptyline has a differential effect on different fiber structures.
BIOSEB Instruments Used
Electronic Von Frey 4 (BIO-EVF4),Electronic Von Frey 5 with embedded camera (BIO-EVF5)
    [meta_description] => 
    [meta_keywords] => https://pubs.asahq.org/anesthesiology/article/108/4/714/8295/Cutaneous-Amitriptyline-in-Human
    [meta_title] => 
    [link_rewrite] => cutaneous-amitriptyline-in-human-volunteers--differential-effects-on-the-components-of-sensory-information
    [actif_langue] => 1
    [read] => 1088
    [count_comments] => 0
    [id] => 1368
    [categories] => Array
        (
            [29] => Array
                (
                    [id_prestablog_categorie] => 29
                    [title] => Neuropathic pain
                    [link_rewrite] => Neuropathic-pain
                )

            [2] => Array
                (
                    [id_prestablog_categorie] => 2
                    [title] => Publications
                    [link_rewrite] => publications
                )

        )

    [authors] => 
    [paragraph_crop] => Cutaneous Amitriptyline in Human Volunteers- Differential Effects on the Components of Sensory [...]
    [link_for_unique] => 1
    [products_liaison] => Array
        (
            [1859] => Array
                (
                    [name] => Electronic Von Frey - Wireless
                    [description_short] => 
A quick solution to determine the mechanical sensitivity threshold in rodents (mice and rats). Now wireless, to be free from annoying cables!

This precise and easy-to-use electronic instrument is a must-have reference for your research in analgesia, nociception, neuro-pathologies and post-operative pain.

                    [thumb] => 
                    [img_empty] => /var/www/vhosts/de3310.ispfr.net/preprod.bioseb.com/modules/prestablog/views/img/product_link_white.jpg
                    [image_presente] => 1
                    [link] => https://preprod.bioseb.com/en/pain-mechanical-allodynia-hyperalgesia/1859-electronic-von-frey-4.html
                )

            [1860] => Array
                (
                    [name] => Electronic Von Frey 5 with embedded camera
                    [description_short] => 
As an electronic version of the classical Von Frey Filaments esthesiometer (or aesthesiometer), the latest evolution of Bioseb's Electronic Von Frey instrument for determining the mechanical sensitivity threshold in rodents (rats and mice) is a must-have instrument for your reseach on hyperalgesia and allodynia. By measuring and recording the force at which the animal exhibits a paw withdrawal reflex, pathologies related to sensory response and hyper- or hypo-aesthesia can be studied.

The EVF5 includes an embedded camera inside the stimulator handle and a new, dedicated software revolutionizing the experimental process.

                    [thumb] => 
                    [img_empty] => /var/www/vhosts/de3310.ispfr.net/preprod.bioseb.com/modules/prestablog/views/img/product_link_white.jpg
                    [image_presente] => 1
                    [link] => https://preprod.bioseb.com/en/pain-mechanical-allodynia-hyperalgesia/1860-electronic-von-frey-5-with-embedded-camera.html
                )

        )

)
1