Publications

Latest publication 12/15/2011

T-bet deficient mice exhibit resistance to stress-induced development of depress

T-bet, a Th1-specific T-box transcription factor, regulates Th1 development by inducing endogenous Th1 cytokines and IFN-_. This study was...

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    [title] => T-bet deficient mice exhibit resistance to stress-induced development of depress
    [paragraph] => T-bet deficient mice exhibit resistance to stress-induced development of depression-like behaviors. 
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Authors
S.-J. Kim, H. Lee, H.-Y. Joung, G. Lee, H.-J. Lee et al. 

 Lab
Kyung-Hee University, College of Oriental Medicine, Department of Physiology, Seoul, Republic of Korea.
Journal
Journal of NeuroImmunology
Abstract
T-bet, a Th1-specific T-box transcription factor, regulates Th1 development by inducing endogenous Th1 cytokines and IFN-_. This study was conducted to determine if T-bet knockout mice exhibit resistance to stress-induced development of depression-like behaviors. The T-bet knockout mice significantly reduced depressive-like behaviors provoked by repeated restraint stress in an elevated plus-maze test (EPM), tail suspension test (TST), and forced swim test (FST). Moreover, stress-induced elevations of the pro-inflammatory cytokines were attenuated in T-bet deficient group. These results suggest that T-bet directly mediated stress-induced depression. Therefore, understanding T-bet function during stress represents an additional treatment strategy for depression.
BIOSEB Instruments Used
Tail Suspension Test - Wireless (BIO-TST5)
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Bioseb's version 5 of the Tail Suspension Test system, based on both strain sensors and video acquisition, is the only fully automatic solution in the world for running a simple and objective despair test on mice. It is a fast, painless, and reliable way for testing psychotropic effects from stimulant doses of drugs such as anti-depressants and sedatives. This classic and painless research test for anxiety and depression is now offered with a new, powerful and modern software, in a wireless, bluetooth-based version.

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