Publications

Latest publication 10/31/2005

The novel analgesic- F 13640- produces intra- and postoperative analgesia in a r

F 13640 is a newly discovered high-efficacy 5-HT1A receptor agonist that produces exceptional analgesia in animal models of tonic and chronic,...

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    [title] => The novel analgesic- F 13640- produces intra- and postoperative analgesia in a r
    [paragraph] => The novel analgesic, F 13640, produces intra- and postoperative analgesia in a rat model of surgical pain.
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Authors
I. Kiss, A.-D. Degryse, L. Bardin, I. A. Gomez de Segura, F. C. Colpaert et al.

 Lab
Klinik für Anästhesie, Intensivmedizin und Schmerztherapie, Alfried Krupp Krankenhaus, Essen, Germany ; Centre de Recherche Pierre Fabre, Castres, France ; Hospital Universitario La Paz, Department of Experimental Surgery, Madrid, Spain.
Journal
European Journal of Pharmacology
Abstract
F 13640 is a newly discovered high-efficacy 5-HT1A receptor agonist that produces exceptional analgesia in animal models of tonic and chronic, nociceptive and neuropathic pains by novel molecular and neuroadaptive mechanisms. Here we examined the effects of F 13640 and remifentanil (0.63 mg/kg with either compound) when injected i.p. either before or 15 min after rats underwent orthopedic surgery. Surgery consisted of the drilling of a hole in the calcaneus bone and of an incision of the skin, fascia and plantar muscle of one foot. During surgery, the concentration of volatile isoflurane was progressively incremented depending on the animal's response to surgical maneuvers. Other experiments examined the dose-dependent effects of F 13640 (0.04 to 0.63 mg/kg) on surgical pain as well as on the Minimum Alveolar Concentration of isoflurane. Both F 13640 and remifentanil markedly reduced the intra-operative isoflurane requirement. F 13640 also reduced measures of postoperative pain (i.e., paw elevation and flexion). With these postoperative measures, remifentanil produced short-lived analgesia followed by hyperalgesia. F 13640 significantly reduced both surgical pain and the isoflurane Minimum Alveolar Concentration from 0.16 mg/kg onward. F 13640 produced powerful intra- and postoperative analgesia in rats undergoing orthopedic surgery. Unlike the opioid, remifentanil, F 13640 caused no hyperalgesia with ongoing postoperative pain, and should remain effective with protracted postoperative use.
BIOSEB Instruments Used
Electronic Von Frey 4 (BIO-EVF4),Electronic Von Frey 5 with embedded camera (BIO-EVF5)
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A quick solution to determine the mechanical sensitivity threshold in rodents (mice and rats). Now wireless, to be free from annoying cables!

This precise and easy-to-use electronic instrument is a must-have reference for your research in analgesia, nociception, neuro-pathologies and post-operative pain.

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The EVF5 includes an embedded camera inside the stimulator handle and a new, dedicated software revolutionizing the experimental process.

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