Publications

Latest publication 08/01/2013

Opiates Modulate Thermosensation by Internalizing Cold Receptor TRPM8

Stimulation of μ-opioid receptors (OPRMs) brings powerful pain relief, but it also leads to the development of tolerance and addiction....

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    [title] => Opiates Modulate Thermosensation by Internalizing Cold Receptor TRPM8
    [paragraph] => Opiates Modulate Thermosensation by Internalizing Cold Receptor TRPM8
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Authors
G. Shapovalov, D. Gkika, M. Devilliers, A. Kondratskyi, D. Gordienko et al.

 Lab
Bogomoletz Institute of Physiology, Kiev , Ukraine
Journal
Cell Reports
Abstract
Stimulation of μ-opioid receptors (OPRMs) brings powerful pain relief, but it also leads to the development of tolerance and addiction. Ensuing withdrawal in abstinent patients manifests itself with severe symptoms, including cold hyperalgesia, often preventing addicted patients from successfully completing the rehabilitation. Unsurprisingly, OPRMs have been a central point of many studies. Nonetheless, a satisfactory understanding of the pathways leading to distorted sensory responses during opiate administration and abstinence is far from complete. Here, we present a mechanism that leads to modulation by OPRMs of one of the sensory responses, thermosensation. Activation of OPRM1 leads to internalization of a cold-sensor TRPM8, which can be reversed by a follow-up treatment with the inverse OPRM agonist naloxone. Knockout of TRPM8 protein leads to a decrease in morphine-induced cold analgesia. The proposed pathway represents a universal mechanism that is probably shared by regulatory pathways modulating general pain sensation in response to opioid treatment.
BIOSEB Instruments Used
Cold Hot Plate Test (BIO-CHP)
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For testing animal's thermal sensitivity to pain resulting from exposure to heat or cold: the Cold Hot Plate is an innovative instrument opening new investigation fields for your analgesia and nociception research, and a useful tool for analgesic drug screening using rats or mice models.

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