Toxicology Scientific Publications

Latest publication 02/10/2021

Herbal-Based Formulation Containing Eurycoma longifolia and Labisia pumila Aqueo

A combined polyherbal formulation containing tongkat ali (Eurycoma longifolia) and kacip fatimah (Labisia pumila) aqueous extracts was evaluated...

Array
(
    [id_prestablog_news] => 1375
    [id_shop] => 1
    [date] => 2021-02-10 00:00:00
    [date_modification] => 2024-02-09 14:15:12
    [langues] => ["1","2"]
    [actif] => 1
    [slide] => 0
    [url_redirect] => 
    [average_rating] => 
    [number_rating] => 
    [author_id] => 1
    [featured] => 0
    [prim_key] => 2921
    [id_lang] => 1
    [title] => Herbal-Based Formulation Containing Eurycoma longifolia and Labisia pumila Aqueo
    [paragraph] => Herbal-Based Formulation Containing Eurycoma longifolia and Labisia pumila Aqueous Extracts- Safe for Consumption?
    [content] => 
Authors
BP Teh, N Ahmad, EN Ibnu Rasid et al

 Lab
Herbal Medicine Research Centre, Institute for Medical Research, National Institutes of Health, Ministry of Health Malaysia, Shah Alam 40170, Selangor Darul Ehsan, Malaysia
Journal
Pharmaceuticals
Abstract
A combined polyherbal formulation containing tongkat ali (Eurycoma longifolia) and kacip fatimah (Labisia pumila) aqueous extracts was evaluated for its safety aspect. A repeated dose 28-day toxicity study using Wistar rats was conducted where the polyherbal formulation was administered at doses 125, 500 and 2000 mg/kg body weight to male and female treatment groups daily via oral gavage, with rats receiving only water as the control group. In-life parameters measured include monitoring of food and water consumption and clinical and functional observations. On day 29, blood was collected for haematological and biochemical analysis. The rats were necropsied and the organs were collected for histopathological examination. This study showed that the combined formulation did not induce any significant toxicity effect at any dose level in terms of morbidity, mortality, behaviour, functional observation, body weight, food and water consumption, whole blood haematology and serum biochemistry. However, there were some microscopic changes in the histopathological examinations of some organs given 2000 mg/kg body weight, which may suggest an early response to the polyherbal formulation. From this study, the no observed adverse effect level is estimated to be more than 500 mg/kg body weight but not exceeding 2000 mg/kg body weight. The observed effects at the highest dose indicate the need for further study of longer dosing duration.
BIOSEB Instruments Used
Grip strength test (BIO-GS3)
    [meta_description] => 
    [meta_keywords] => https://doi.org/10.3390/ph14020142www.mdpi.com/journal/pharmaceuticals 
    [meta_title] => 
    [link_rewrite] => herbal-based-formulation-containing-eurycoma-longifolia-and-labisia-pumila-aqueous-extracts--safe-for-consumption
    [actif_langue] => 1
    [read] => 975
    [count_comments] => 0
    [id] => 1375
    [categories] => Array
        (
            [2] => Array
                (
                    [id_prestablog_categorie] => 2
                    [title] => Publications
                    [link_rewrite] => publications
                )

            [94] => Array
                (
                    [id_prestablog_categorie] => 94
                    [title] => Toxicology
                    [link_rewrite] => Toxicology
                )

        )

    [authors] => 
    [paragraph_crop] => Herbal-Based Formulation Containing Eurycoma longifolia and Labisia pumila Aqueous Extracts- [...]
    [link_for_unique] => 1
    [products_liaison] => Array
        (
            [48] => Array
                (
                    [name] => Grip strength test
                    [description_short] => 
An easy way to objectively quantify the muscular strength of mice and rats, and to assess the effect of drugs, toxins, muscular (i.e. myopathy) and neurodegenerative diseases on muscular degeneration. It is widely used in conjunction with the ROTAROD motor coordination test: a normally coordinated rodent will show a decreased latency to fall off the rotating rod if its muscular strength is low. The Grip Strength Test is a must for your research on activity, motor control & coordination, and is particularly well suited for studies on Parkinson's & Huntington's disease.
New features GS4 - 2023: Color display with permanent backlight screen for easier reading, reset by footswitch, Improved battery time, Larger data memory of 500 values, Animal counter, USB port (charging/data transfer)

                    [thumb] => 
                    [img_empty] => /var/www/vhosts/de3310.ispfr.net/preprod.bioseb.com/modules/prestablog/views/img/product_link_white.jpg
                    [image_presente] => 1
                    [link] => https://preprod.bioseb.com/en/activity-motor-control-coordination/48-grip-strength-test.html
                )

        )

)
1