Publications

Latest publication 05/30/2001

Assessment of neurotoxicity following repeated cremophor and ethanol injection

As the mixture cremophor/ethanol is known to have side-effects affecting the peripheral nervous system, we have assessed its behavioural and...

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    [title] => Assessment of neurotoxicity following repeated cremophor  and  ethanol injection
    [paragraph] => Assessment of neurotoxicity following repeated cremophor / ethanol injections in rats.
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Authors
N. Authier, J.-P. Gillet, J. Fialip, A. Eschalier, F. Coudore.

 Lab
Université d’ Auvergne (INSERM EMI 9904), Laboratoire de Toxicologie, Equipe NeuroPsychoPharmacologie, Clermont-Ferrand, France.
Journal
Neurotoxicity Research
Abstract
As the mixture cremophor/ethanol is known to have side-effects affecting the peripheral nervous system, we have assessed its behavioural and morphological neurotoxicity after repeated intraperitoneal injections in male Sprague Dawley rats. Clinical status of the animals was good throughout the experiment and no motor deficits were observed. Nevertheless, sensory testing demonstrated an hyperalgesia and an allodynia to mechanical stimuli, associated to peripheral axon degeneration.
BIOSEB Instruments Used
Grip strength test (BIO-GS3)
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An easy way to objectively quantify the muscular strength of mice and rats, and to assess the effect of drugs, toxins, muscular (i.e. myopathy) and neurodegenerative diseases on muscular degeneration. It is widely used in conjunction with the ROTAROD motor coordination test: a normally coordinated rodent will show a decreased latency to fall off the rotating rod if its muscular strength is low. The Grip Strength Test is a must for your research on activity, motor control & coordination, and is particularly well suited for studies on Parkinson's & Huntington's disease.
New features GS4 - 2023: Color display with permanent backlight screen for easier reading, reset by footswitch, Improved battery time, Larger data memory of 500 values, Animal counter, USB port (charging/data transfer)

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