Publications

Latest publication 05/01/2022

Comprehensive Evaluation of Long-term Dynamic Mechanical Behavior in a Rat MIA O

Osteoarthritis (OA) is highly prevalent across the world with 30% of the US population who are 45 and older estimated to have knee osteoarthritis....

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    [title] => Comprehensive Evaluation of Long-term Dynamic Mechanical Behavior in a Rat MIA O
    [paragraph] => Comprehensive Evaluation of Long-term Dynamic Mechanical Behavior in a Rat MIA OA Model
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Authors
D Kishnan, E Orozco, L Nair 

 Lab
Department of Biomedical Engineering, University of Connecticut, USA
Journal
The Journal of Pain
Abstract
Osteoarthritis (OA) is highly prevalent across the world with 30% of the US population who are 45 and older estimated to have knee osteoarthritis. The primary clinical indication of OA is pain. Mono-iodo acetate (MIA) induced osteoarthritis is commonly used to study pain in pre-clinical models. Currently mechanical allodynia and thermal hyperalgesia are used to measure the pain outcomes in most pre-clinical models however, the non-evoked dynamic weight bearing analysis provides more clinically relevant behavioral assessment of pain. The goal of the study is to comprehensively understand the changes in dynamic weight bearing behavior of rats with MIA induced OA over a period of 16 weeks. Osteoarthritis was induced in female Sprague-Dawley rats by C-arm guided injections of MIA (3 mg) into the intra-articular region of the right knee. Non-evoked dynamic weight bearing was evaluated using a pressure sensor system (Bioseb DWB 2.0), mechanical allodynia using Von Frey filaments, and transcriptional changes at the dorsal root ganglion using BioRad gene array. MIA model showed mechanical allodynia of the ipsilateral paw for over 3 months. The dynamic weight bearing parameters reveal continuous compensatory weight preference towards the uninjured limbs for the same period. Unlike Von Frey, significantly different dynamic behavioral parameters begin to appear within 24 hours post MIA injection. Moreover, parameters related to weight and area distribution showed temporal changes over the course of the study. The study shows that dynamic weight bearing assessment is an effective tool to understand the long-term progression of pain behavior in a MIA model.
BIOSEB Instruments Used
Dynamic Weight Bearing 2.0 (BIO-DWB-DUAL)
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The advanced version of our Dynamic Weight Bearing Test for rodents (rats and mice) allows for faster paw identification, based on a video solution taking advantage of the most advanced algorithms of morphologic analysis, weight distribution and postural changes in dynamic conditions. An efficient and advanced alternative to traditional incapacitance tests (i.e. the paw pressure test or the force plate test) for assessing pain sensitivity in your research on analgesia, hyperalgesia and nociception involving rats and mice, including work on osteoarthritis, bone cancer, analgesic substances, Parkinson disease, allodynia...

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Expand Your Analysis with Advanced Postural and Locomotor Calculations
BIOSEB’s renowned Dynamic Weight Bearing (DWB2) system is now more powerful than ever with the addition of the Postural Module. This optional software upgrade extends standard weight-bearing analysis by integrating unique calculations designed to quantify subtle aspects of postural balance, locomotor patterns, and compensatory behaviors.
Developed in collaboration with Dr. Tighilet’s lab from Aix Marseille Université-CNRS, the Postural Module improves your DWB2, providing valuable endpoints for studies on pain, neurology, vestibular dysfunction, and neurodegenerative disorders.

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