Pharmacology Scientific Publications

Latest publication 10/27/2015

Pharmacodynamic Evaluation of Sustained Release of PEG and PLA Formulation Inclu

The inclusion of local anesthetic (LA) in a gel of poly (lactic-co-glycol) acid (PEG/PLA) sustained release formulation (SRF) allow an prolonged...

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    [title] => Pharmacodynamic Evaluation of Sustained Release of PEG and PLA Formulation Inclu
    [paragraph] => Pharmacodynamic Evaluation of Sustained Release of PEG/PLA Formulation Including Bupivacaïne or Ropivacaïne versus 0.25% Bupivacaïne After Sciatic Nerve Block in Rat
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Authors
Bertrand Abbal et al.

 Lab
Montpellier University Hospital of Lapeyronie - INSERM U1046, Montpellier, France
Journal
Anaesthesia
Abstract
The inclusion of local anesthetic (LA) in a gel of poly (lactic-co-glycol) acid (PEG/PLA) sustained release formulation (SRF) allow an prolonged duration of LA from only a single injection (1). The prolonged LA release, during polymer degradation, could ensure a long term control of postoperative acute pain. The main objective of this study was to assess the pharmacodynamic profile of the new formulation of bupivacaïne or ropivacaïne with SRF compared to 0.25% bupivacaïne (Bupi) during sciatic nerve blocks in rat.
BIOSEB Instruments Used
Rodent pincher - analgesia meter (BIO-RP-M)
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A fast and accurate algometer based on an instrumented pincher as an alternative to the Randall-Selitto test: This new analgesia meter developed by Bioseb following Luis-Delgado et al. (2005) allows accurate nociceptive tests to measure mechanical pain threshold on rat or mouse limbs with minimal constraint. Now wireless, to be free from annoying cables!

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