Spontaneous pain Scientific Publications

Latest publication 06/02/2022

Objective and Quantitative Evaluation of Spontaneous Pain-Like Behaviors Using D

The paucity of objective and reliable measurements of pain-like behaviors has impeded the translatability of mouse models of postsurgical pain. The...

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    [title] => Objective and Quantitative Evaluation of Spontaneous Pain-Like Behaviors Using D
    [paragraph] => Objective and Quantitative Evaluation of Spontaneous Pain-Like Behaviors Using Dynamic Weight-Bearing System in Mouse Models of Postsurgical Pain
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Authors
F Lu, J Kato, T Toramaru et al

 Lab
Department of Anesthesiology, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan
Journal
Journal of Pain Research
Abstract
The paucity of objective and reliable measurements of pain-like behaviors has impeded the translatability of mouse models of postsurgical pain. The advanced dynamic weight-bearing (DWB) system enables evaluation of spontaneous pain-like behaviors in pain models. This study investigated the suitability and efficiency of the DWB system for assessing spontaneous pain-like behaviors and analgesic therapies in murine models of postsurgical pain.
BIOSEB Instruments Used
Dynamic Weight Bearing 2.0 (BIO-DWB-DUAL)
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The advanced version of our Dynamic Weight Bearing Test for rodents (rats and mice) allows for faster paw identification, based on a video solution taking advantage of the most advanced algorithms of morphologic analysis, weight distribution and postural changes in dynamic conditions. An efficient and advanced alternative to traditional incapacitance tests (i.e. the paw pressure test or the force plate test) for assessing pain sensitivity in your research on analgesia, hyperalgesia and nociception involving rats and mice, including work on osteoarthritis, bone cancer, analgesic substances, Parkinson disease, allodynia...

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Expand Your Analysis with Advanced Postural and Locomotor Calculations
BIOSEB’s renowned Dynamic Weight Bearing (DWB2) system is now more powerful than ever with the addition of the Postural Module. This optional software upgrade extends standard weight-bearing analysis by integrating unique calculations designed to quantify subtle aspects of postural balance, locomotor patterns, and compensatory behaviors.
Developed in collaboration with Dr. Tighilet’s lab from Aix Marseille Université-CNRS, the Postural Module improves your DWB2, providing valuable endpoints for studies on pain, neurology, vestibular dysfunction, and neurodegenerative disorders.

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