Publications

Latest publication 08/01/2019

EFFECT OF 1-HYDROXY-1-1-ETHYLIDENDIPHOSPHONE ACID- BIS-2-PYRIDYL-1-2-4-TRIAZOLYL

The aim of the work is to evaluate the effect of 1-hydroxy-1,1-ethylidenediphosphonic acid, bis(2-pyridyl-1,2,4-triazolyl-3)propane and their...

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    [title] => EFFECT OF 1-HYDROXY-1-1-ETHYLIDENDIPHOSPHONE ACID- BIS-2-PYRIDYL-1-2-4-TRIAZOLYL
    [paragraph] => EFFECT OF 1-HYDROXY-1,1-ETHYLIDENDIPHOSPHONE ACID, BIS(2-PYRIDYL-1,2,4-TRIAZOLYL-3)PROPANE AND THEIR ADDUCT ON THE PAIN SENSITIVITY OF RATS PYRIDYL-1,2,4-TRIAZOLYL-3)PROPANE AND THEIR ADDUCT ON THE PAIN SENSITIVITY OF RATS
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Authors
Cheretaev I. V., Ravaeva M. Yu., Dzheldubaeva E. R, et al

 Lab
V. I. Vernadsky Crimean Federal University, Simferopol, Crimea, Russia
Journal
Scientific notes of the Crimean Federal University named after V.I. Vernadsky
Abstract
The aim of the work is to evaluate the effect of 1-hydroxy-1,1-ethylidenediphosphonic acid, bis(2-pyridyl-1,2,4-triazolyl-3)propane and their adduct on the pain sensitivity of male rats in the dose range from 5 to 200 mg/kg.
BIOSEB Instruments Used
Cold Hot Plate Test (BIO-CHP),Rodent pincher - analgesia meter (BIO-RP-M)
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For testing animal's thermal sensitivity to pain resulting from exposure to heat or cold: the Cold Hot Plate is an innovative instrument opening new investigation fields for your analgesia and nociception research, and a useful tool for analgesic drug screening using rats or mice models.

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A fast and accurate algometer based on an instrumented pincher as an alternative to the Randall-Selitto test: This new analgesia meter developed by Bioseb following Luis-Delgado et al. (2005) allows accurate nociceptive tests to measure mechanical pain threshold on rat or mouse limbs with minimal constraint. Now wireless, to be free from annoying cables!

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