Motor control Scientific Publications

Latest publication 08/22/2019

Sp1-regulated expression of p11 contributes to motor neuron degeneration by memb

Disruption in membrane excitability contributes to malfunction and differential vulnerability of specific neuronal subpopulations in a number of...

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    [title] => Sp1-regulated expression of p11 contributes to motor neuron degeneration by memb
    [paragraph] => Sp1-regulated expression of p11 contributes to motor neuron degeneration by membrane insertion of TASK1
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Authors
V Garc’a-Morales, G Rodr’guez-Bey, L G—mez-PŽrez et al

 Lab
Grupo de Neurodegeneraci—n y Neurorreparaci—n (GRUNEDERE), Universidad de C‡diz, 11003 C‡diz, Spain
Journal
Nature Communications
Abstract
Disruption in membrane excitability contributes to malfunction and differential vulnerability of specific neuronal subpopulations in a number of neurological diseases. The adaptor protein p11, and background potassium channel TASK1, have overlapping distributions in the CNS. Here, we report that the transcription factor Sp1 controls p11 expression, which impacts on excitability by hampering functional expression of TASK1. In the SOD1-G93A mouse model of ALS, Sp1-p11-TASK1 dysregulation contributes to increased excitability and vulnerability of motor neurons. Interference with either Sp1 or p11 is neuroprotective, delaying neuron loss and prolonging lifespan in this model. Nitrosative stress, a potential factor in human neurodegeneration, stimulated Sp1 expression and human p11 promoter activity, at least in part, through a Sp1-binding site. Disruption of Sp1 or p11 also has neuroprotective effects in a traumatic model of motor neuron degeneration. Together our work suggests the Sp1-p11-TASK1 pathway is a potential target for treatment of degeneration of motor neurons.
BIOSEB Instruments Used
Grip strength test (BIO-GS3)
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An easy way to objectively quantify the muscular strength of mice and rats, and to assess the effect of drugs, toxins, muscular (i.e. myopathy) and neurodegenerative diseases on muscular degeneration. It is widely used in conjunction with the ROTAROD motor coordination test: a normally coordinated rodent will show a decreased latency to fall off the rotating rod if its muscular strength is low. The Grip Strength Test is a must for your research on activity, motor control & coordination, and is particularly well suited for studies on Parkinson's & Huntington's disease.
New features GS4 - 2023: Color display with permanent backlight screen for easier reading, reset by footswitch, Improved battery time, Larger data memory of 500 values, Animal counter, USB port (charging/data transfer)

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