Miscellaneous research domains - page 14 Scientific Publications

Latest publication 04/24/2014

Neurodegenerative changes are prevented by Erythropoietin in the pmn model of mo

Motoneuron diseases are fatal neurodegenerative disorders characterized by a progressive loss of motoneurons, muscle weakness and premature death....

Array
(
    [id_prestablog_news] => 583
    [id_shop] => 1
    [date] => 2014-04-24 00:00:00
    [date_modification] => 2024-02-09 14:15:11
    [langues] => ["1","2"]
    [actif] => 1
    [slide] => 0
    [url_redirect] => 
    [average_rating] => 
    [number_rating] => 
    [author_id] => 1
    [featured] => 0
    [prim_key] => 1141
    [id_lang] => 1
    [title] => Neurodegenerative changes are prevented by Erythropoietin in the pmn model of mo
    [paragraph] => Neurodegenerative changes are prevented by Erythropoietin in the pmn model of motoneuron degeneration
    [content] => 
Authors
M. Ruiz, A. F. Martínez-Vidala J. M. Morales, D. Monleón, M. Giménez et al.

 Lab
Universidad Miguel Hernández (UMH), San Juan de Alicante, Spain
Journal
Neuropharmacology
Abstract
Motoneuron diseases are fatal neurodegenerative disorders characterized by a progressive loss of motoneurons, muscle weakness and premature death. The progressive motor neuronopathy (pmn) mutant mouse has been considered a good model for the autosomal recessive childhood form of spinal muscular atrophy (SMA). Here, we investigated the therapeutic potential of Erythropoietin (Epo) on this mutant mouse. Symptomatic or pre-symptomatic treatment with Epo significantly prolongs lifespan by 84.6% or 87.2% respectively. Epo preserves muscle strength and significantly attenuates behavioural motor deficits of mutant pmn mice. Histological and metabolic changes in the spinal cord evaluated by immunohistochemistry, western blot, and high-resolution 1H-NMR spectroscopy were also greatly prevented by Epo-treatment. Our results illustrate the efficacy of Epo in improving quality of life of mutant pmn mice and open novel therapeutic pathways for motoneuron diseases.
BIOSEB Instruments Used
Grip strength test (BIO-GS3)
    [meta_description] => 
    [meta_keywords] => http://www.sciencedirect.com/science/article/pii/S002839081400135X
    [meta_title] => 
    [link_rewrite] => neurodegenerative-changes-are-prevented-by-erythropoietin-in-the-pmn-model-of-motoneuron-degeneration
    [actif_langue] => 1
    [read] => 1066
    [count_comments] => 0
    [id] => 583
    [categories] => Array
        (
            [26] => Array
                (
                    [id_prestablog_categorie] => 26
                    [title] => Miscellaneous research domains
                    [link_rewrite] => Miscellaneous-research-domains
                )

            [2] => Array
                (
                    [id_prestablog_categorie] => 2
                    [title] => Publications
                    [link_rewrite] => publications
                )

        )

    [authors] => 
    [paragraph_crop] => Neurodegenerative changes are prevented by Erythropoietin in the pmn model of motoneuron [...]
    [link_for_unique] => 1
    [products_liaison] => Array
        (
            [48] => Array
                (
                    [name] => Grip strength test
                    [description_short] => 
An easy way to objectively quantify the muscular strength of mice and rats, and to assess the effect of drugs, toxins, muscular (i.e. myopathy) and neurodegenerative diseases on muscular degeneration. It is widely used in conjunction with the ROTAROD motor coordination test: a normally coordinated rodent will show a decreased latency to fall off the rotating rod if its muscular strength is low. The Grip Strength Test is a must for your research on activity, motor control & coordination, and is particularly well suited for studies on Parkinson's & Huntington's disease.
New features GS4 - 2023: Color display with permanent backlight screen for easier reading, reset by footswitch, Improved battery time, Larger data memory of 500 values, Animal counter, USB port (charging/data transfer)

                    [thumb] => 
                    [img_empty] => /var/www/vhosts/de3310.ispfr.net/preprod.bioseb.com/modules/prestablog/views/img/product_link_white.jpg
                    [image_presente] => 1
                    [link] => https://preprod.bioseb.com/en/activity-motor-control-coordination/48-grip-strength-test.html
                )

        )

)
1