Inflammatory pain - page 6 Scientific Publications

Latest publication 12/14/2005

Inflammatory Pain Upregulates Spinal Inhibition via Endogenous Neurosteroid Prod

Inhibitory synaptic transmission in the dorsal horn (DH) of the spinal cord plays an important role in the modulation of nociceptive messages...

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    [title] => Inflammatory Pain Upregulates Spinal Inhibition via Endogenous Neurosteroid Prod
    [paragraph] => Inflammatory Pain Upregulates Spinal Inhibition via Endogenous Neurosteroid Production.
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Authors
P. Poisbeau, C. Patte-Mensah, A. F. Keller, M. Barrot, J.-D. Breton et al.

 Lab
Centre National de la Recherche Scientifique/Université Louis Pasteur, Institut des Neurosciences Cellulaires et Intégratives, Strasbourg, France.
Journal
The Journal of Neurosciences
Abstract
Inhibitory synaptic transmission in the dorsal horn (DH) of the spinal cord plays an important role in the modulation of nociceptive messages because pharmacological blockade of spinal GABAA receptors leads to thermal and mechanical pain symptoms. Here, we show that during the development of thermal hyperalgesia and mechanical allodynia associated with inflammatory pain, synaptic inhibition mediated by GABAA receptors in lamina II of the DH was in fact markedly increased. This phenomenon was accompanied by an upregulation of the endogenous production of 5_-reduced neurosteroids, which, at the spinal level, led to a prolongation of GABAA receptor-mediated synaptic currents and to the appearance of a mixed GABA/glycine cotransmission. This increased inhibition was correlated with a selective limitation of the inflammation-induced thermal hyperalgesia, whereas mechanical allodynia remained unaffected. Our results show that peripheral inflammation activates an endogenous neurosteroid-based antinociceptive control, which discriminates between thermal and mechanical hyperalgesia.
BIOSEB Instruments Used
Rodent pincher - analgesia meter (BIO-RP-M)
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A fast and accurate algometer based on an instrumented pincher as an alternative to the Randall-Selitto test: This new analgesia meter developed by Bioseb following Luis-Delgado et al. (2005) allows accurate nociceptive tests to measure mechanical pain threshold on rat or mouse limbs with minimal constraint. Now wireless, to be free from annoying cables!

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