Depression - page 6 Scientific Publications

Latest publication 09/30/2006

Early behavioral screening for antidepressants and anxiolytics-

Early preclinical behavioral testing is an essential stage during the development of substances with potential antidepressant and/or anxiolytic...

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    [title] => Early behavioral screening for antidepressants and anxiolytics-
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Authors
V. Castagné, R. D. Porsolt, P. Moser.

 Lab
Porsolt & Partners Pharmacology, Boulogne-Billancourt, France
Journal
Drug Development Research
Abstract
Early preclinical behavioral testing is an essential stage during the development of substances with potential antidepressant and/or anxiolytic activity. With the growing cost of drug development, optimal research strategies are needed to detect potential new treatments with high efficacy and minimal side effects and to confirm in vitro pharmacological studies. In the following article, we present simple rodent tests used for early behavioral testing for antidepressant-like and anxiolytic-like activity. Unpublished results from our laboratory are discussed with reference to published data to illustrate the predictive validity of several behavioral screening tests.
BIOSEB Instruments Used
Tail Suspension Test - Wireless (BIO-TST5)
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Bioseb's version 5 of the Tail Suspension Test system, based on both strain sensors and video acquisition, is the only fully automatic solution in the world for running a simple and objective despair test on mice. It is a fast, painless, and reliable way for testing psychotropic effects from stimulant doses of drugs such as anti-depressants and sedatives. This classic and painless research test for anxiety and depression is now offered with a new, powerful and modern software, in a wireless, bluetooth-based version.

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