Publications

Latest publication 08/01/2017

Antinociceptive and antipyretic properties of ethanol extract of Oryza bathii -P

Ethanol extract of Oryza barthii obtained by cold maceration was investigated for antinociceptive and antipyretic activities using the hot plate...

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    [title] => Antinociceptive and antipyretic properties of ethanol extract of Oryza bathii -P
    [paragraph] => Antinociceptive and antipyretic properties of ethanol extract of Oryza bathii (Poaceae) in wistar rats
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Authors
E.O. Abidoye, I Aplakah

 Lab
Department of Veterinary Surgery and Radiology, Ahmadu Bello University, Zaria, Nigeria
Journal
Sokoto Journal of Veterinary Sciences
Abstract
Ethanol extract of Oryza barthii obtained by cold maceration was investigated for antinociceptive and antipyretic activities using the hot plate and brewer’s yeast-induced hyperthermia methods, respectively in adult wistar rats. The medications used as positive control were piroxicam at 20 mg/kg intra-peritoneal (i.p) for the antinociceptive study and aspirin at 100 mg/kg i.p. for the antipyretic study and both induced significant delay in the reaction time of the rats to thermal stimulus and hyperthermia respectively. Oryza barthii (Poaceae) extract administered at dosages of between 125 – 500 mg/kg i.p, significantly delayed the reaction time of rats to thermal stimulus produced by the hot plate and reduced the hyperthermia in a dose-dependent manner. The results showed that O. barthii possesses antinociceptive and antipyretic activities, thus justifying the folklore use of the plant in traditional medicine for the control of fever and can be an alternative medicament in the management of pyrexia.
BIOSEB Instruments Used
Cold Hot Plate Test (BIO-CHP)
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For testing animal's thermal sensitivity to pain resulting from exposure to heat or cold: the Cold Hot Plate is an innovative instrument opening new investigation fields for your analgesia and nociception research, and a useful tool for analgesic drug screening using rats or mice models.

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