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Latest publication 02/18/2015

Candesartan restores pressure-induced vasodilation and prevents skin pressure ul

Angiotensin II type 1 receptor (AT1R) blockers have beneficial effects on neurovascular complications in diabetes and in organ’s protection against...

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    [title] => Candesartan restores pressure-induced vasodilation and prevents skin pressure ul
    [paragraph] => Candesartan restores pressure-induced vasodilation and prevents skin pressure ulcer formation in diabetic mice
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Authors
Aurore Danigo, Mohamad Nasser, Flavien Bessaguet, James Javellaud, Nicole Oudart, Jean-Michel Achard, and Claire Demiotcorresponding author



 Lab
EA6309, School of Medecine and Pharmacy, University of Limoges, Limoges, France


Journal
Cardiovasc Diabetol


Abstract
Angiotensin II type 1 receptor (AT1R) blockers have beneficial effects on neurovascular complications in diabetes and in organ’s protection against ischemic episodes. The present study examines whether the AT1R blocker candesartan (1) has a beneficial effect on diabetes-induced alteration of pressure-induced vasodilation (PIV, a cutaneous physiological neurovascular mechanism which could delay the occurrence of tissue ischemia), and (2) could be protective against skin pressure ulcer formation.

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