Publications

Latest publication 09/01/2021

Inhibition of endothelin A receptor by a novel- selective receptor antagonist en

The misuse of opioids has led to an epidemic in recent times. The endothelin A receptor (ETAR) has recently attracted attention as a novel...

Array
(
    [id_prestablog_news] => 1411
    [id_shop] => 1
    [date] => 2021-09-01 00:00:00
    [date_modification] => 2024-02-09 14:15:13
    [langues] => ["1","2"]
    [actif] => 1
    [slide] => 0
    [url_redirect] => 
    [average_rating] => 
    [number_rating] => 
    [author_id] => 1
    [featured] => 0
    [prim_key] => 2994
    [id_lang] => 1
    [title] => Inhibition of endothelin A receptor by a novel- selective receptor antagonist en
    [paragraph] => Inhibition of endothelin A receptor by a novel- selective receptor antagonist enhances morphine-induced analgesia- Possible functional interaction of dimerized endothelin A and mu-opioid receptors
    [content] => 
Authors
Y Kurodaab,M Nonakab, Y Kamikubo et al



 Lab
The Jikei University School of Medicine, Minato-ku, Tokyo, Japan.


Journal
Biomedicine & Pharmacotherapy


Abstract
The misuse of opioids has led to an epidemic in recent times. The endothelin A receptor (ETAR) has recently attracted attention as a novel therapeutic target to enhance opioid analgesia. We hypothesized that endothelin A receptors may affect pain mechanisms by heterodimerization with mu-opioid receptors. We examined the mechanisms of ETAR-mediated pain and the potential therapeutic effects of an ETAR antagonist, Compound-E, as an agent for analgesia.
BIOSEB Instruments Used
Rodent pincher - analgesia meter (BIO-RP-M)

    [meta_description] => 
    [meta_keywords] => https://doi.org/10.1016/j.biopha.2021.111800
    [meta_title] => 
    [link_rewrite] => inhibition-of-endothelin-a-receptor-by-a-novel--selective-receptor-antagonist-enhances-morphine-induced-analgesia--possible-functional-interaction-of-dimerized-endothelin-a-and-mu-opioid-receptors
    [actif_langue] => 1
    [read] => 984
    [count_comments] => 0
    [id] => 1411
    [categories] => Array
        (
            [27] => Array
                (
                    [id_prestablog_categorie] => 27
                    [title] => General pain
                    [link_rewrite] => General-pain
                )

            [2] => Array
                (
                    [id_prestablog_categorie] => 2
                    [title] => Publications
                    [link_rewrite] => publications
                )

        )

    [authors] => 
    [paragraph_crop] => Inhibition of endothelin A receptor by a novel- selective receptor antagonist enhances [...]
    [link_for_unique] => 1
    [products_liaison] => Array
        (
            [1218] => Array
                (
                    [name] => Rodent pincher - Analgesia meter - Wireless
                    [description_short] => 
A fast and accurate algometer based on an instrumented pincher as an alternative to the Randall-Selitto test: This new analgesia meter developed by Bioseb following Luis-Delgado et al. (2005) allows accurate nociceptive tests to measure mechanical pain threshold on rat or mouse limbs with minimal constraint. Now wireless, to be free from annoying cables!


Instrument for ratsInstrument for mice

                    [thumb] => 
                    [img_empty] => /var/www/vhosts/de3310.ispfr.net/preprod.bioseb.com/modules/prestablog/views/img/product_link_white.jpg
                    [image_presente] => 1
                    [link] => https://preprod.bioseb.com/en/pain-mechanical-allodynia-hyperalgesia/1218-rodent-pincher-analgesia-meter.html
                )

        )

)
1
Read more

Filters

Clear all

Categories

View all products

Applications

Dates