Miscellaneous research domains - page 23 Scientific Publications

Latest publication 02/01/2012

Prostaglandin E2-Mediated Attenuation of Mesocortical Dopaminergic Pathway Is Cr

Various kinds of stress are thought to precipitate psychiatric disorders, such as major depression. Whereas studies in rodents have suggested a...

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    [title] => Prostaglandin E2-Mediated Attenuation of Mesocortical Dopaminergic Pathway Is Cr
    [paragraph] => Prostaglandin E2-Mediated Attenuation of Mesocortical Dopaminergic Pathway Is Critical for Susceptibility to Repeated Social Defeat Stress in Mice 
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Authors
    Kohei Tanaka Tomoyuki Furuyashiki Shiho Kitaoka Yuta Senzai Yuki Imoto Eri Segi-Nishida Yuichi Deguchi Richard M. Breyer Matthew D. Breyer and Shuh Narumiya

 Lab
Kyoto University Graduate School of Medicine  TOKYO JAPAN
Journal
The journal of neuroscience
Abstract
Various kinds of stress are thought to precipitate psychiatric disorders, such as major depression. Whereas studies in rodents have suggested a critical role of medial prefrontal cortex (mPFC) in stress susceptibility, the mechanism of how stress susceptibility is determined through mPFC remains unknown. Here we show a critical role of prostaglandin E2 (PGE2), a bioactive lipid derived from arachidonic acid, in repeated social defeat stress in mice. Repeated social defeat increased the PGE2 level in the subcortical region of the brain, and mice lacking either COX-1, a prostaglandin synthase, or EP1, a PGE receptor, were impaired in induction of social avoidance by repeated social defeat. Given the reported action of EP1 that augments GABAergic inputs to midbrain dopamine neurons, we analyzed dopaminergic response upon social defeat. Analyses of c-Fos expression of VTA dopamine neurons and dopamine turnover in mPFC showed that mesocortical dopaminergic pathway is activated upon social defeat and attenuated with repetition of social defeat in wild-type mice. EP1 deficiency abolished such repeated stress-induced attenuation of mesocortical dopaminergic pathway. Blockade of dopamine D1-like receptor during social defeat restored social avoidance in EP1-deficient mice, suggesting that disinhibited dopaminergic response during social defeat blocks induction of social avoidance. Furthermore, mPFC dopaminergic lesion by local injection of 6-hydroxydopamine, which mimicked the action of EP1 during repeated stress, facilitated induction of social avoidance upon social defeat. Taken together, our data suggest that PGE2-EP1 signaling is critical for susceptibility to repeated social defeat stress in mice through attenuation of mesocortical dopaminergic pathway. 
BIOSEB Instruments Used
Smart 3.0 - Video Tracking System (SMART30)
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