Fonctions squelettales - Publications Scientifiques

Dernière publication 02/07/2022

Hydrogen sulfide mitigates skeletal muscle mitophagy‐led tissue remodeling via e

Ketone bodies (KB) serve as the food for mitochondrial biogenetics. Interestingly, probiotics are known to promote KB formation in the gut...

Array
(
    [id_prestablog_news] => 1538
    [id_shop] => 1
    [date] => 2022-07-02 00:00:00
    [date_modification] => 2024-02-09 14:15:13
    [langues] => ["1","2"]
    [actif] => 1
    [slide] => 0
    [url_redirect] => 
    [average_rating] => 
    [number_rating] => 
    [author_id] => 1
    [featured] => 0
    [prim_key] => 3303
    [id_lang] => 2
    [title] => Hydrogen sulfide mitigates skeletal muscle mitophagy‐led tissue remodeling via e
    [paragraph] => Hydrogen sulfide mitigates skeletal muscle mitophagy‐led tissue remodeling via epigenetic regulation of the gene writer and eraser function
    [content] => 
Authors
M Singh, S Pushpakumar, Y Zheng et al

 Lab
Department of Physiology, University of Louisville School of Medicine, Louisville, Kentucky, USA
Journal
Physiological Reports
Abstract
Ketone bodies (KB) serve as the food for mitochondrial biogenetics. Interestingly, probiotics are known to promote KB formation in the gut (especially those that belong to the Lactobacillus genus). Furthermore, Lactobacillus helps produce folate that lowers the levels of homocysteine (Hcy); a hallmark non-proteinogenic amino acid that defines the importance of epigenetics, and its landscape. In this study, we decided to test whether hydrogen sulfide (H2S), another Hcy lower ing agent regulates the epigenetic gene writer DNA methyltransferase (DNMT), eraser FTO and TET2, and thus mitigates the skeletal muscle remodeling. We treated hyperhomocysteinemic (HHcy, cystathionine beta-synthase heterozy gote knockout; CBS+/−) mice with NaHS (the H2S donor). The results suggested multi-organ damage by HHcy in the CBS+/−mouse strain compared with WT control mice (CBS+/+). H2S treatment abrogated most of the HHcy-induced dam age. The levels of gene writer (DNMT2) and H3K9 (methylation) were higher in the CBS+/− mice, and the H2S treatment normalized their levels. More im portantly, the levels of eraser FTO, TET, and associated GADD45, and MMP-13 were decreased in the CBS+/− mice; however, H2S treatment mitigated their respective decrease. These events were associated with mitochondrial fission, i.e., an increase in DRP1, and mitophagy. Although the MMP-2 level was lower in CBS+/− compared to WT but H2S could further lower it in the CBS+/− mice. The MMPs levels were associated with an increase in interstitial fibrosis in the BS+/−skeletal muscle. Due to fibrosis, the femoral artery blood flow was reduced in the CBS+/− mice, and that was normalized by H2S. The bone and muscle strengths were found to be decreased in the CBS+/− mice but the H2S treatment normal ized skeletal muscle strength in the CBS+/− mice. Our findings suggest that H2S mitigates the mitophagy-led skeletal muscle remodeling via epigenetic regulation of the gene writer and eraser function
BIOSEB Instruments Used
Grip strength test (BIO-GS3)
    [meta_description] => 
    [meta_keywords] => https://doi.org/10.14814/phy2.15422
    [meta_title] => 
    [link_rewrite] => hydrogen-sulfide-mitigates-skeletal-muscle-mitophagyled-tissue-remodeling-via-epigenetic-regulation-of-the-gene-writer-and-eraser-function
    [actif_langue] => 1
    [read] => 141
    [count_comments] => 0
    [id] => 1538
    [categories] => Array
        (
            [64] => Array
                (
                    [id_prestablog_categorie] => 64
                    [title] => Fonctions squelettales
                    [link_rewrite] => Fonctions-squelettales
                )

            [2] => Array
                (
                    [id_prestablog_categorie] => 2
                    [title] => Publications
                    [link_rewrite] => publications
                )

        )

    [authors] => 
    [paragraph_crop] => Hydrogen sulfide mitigates skeletal muscle mitophagy‐led tissue remodeling via epigenetic r [...]
    [link_for_unique] => 1
    [products_liaison] => Array
        (
            [48] => Array
                (
                    [name] => Test d'agrippement
                    [description_short] => 
Une méthode simple pour quantifier objectivement la force musculaire des rats et souris et l'effet de drogues, toxines, maladies musculaires (ex: myopathie) et neurodégénératives. Cette mesure de force est souvent employée en association avec le test de coordination motrice ROTAROD: un sujet présentant une coordination normale montrera des résultats médiocres en cas de faible force musculaire. Un must pour vos recherches sur l'activité, la coordination et le contrôle musculaire: particulièrement utile pour vos études sur les maladies de Parkinson et Huntington.
Nouveautés GS4 - 2023: Écran couleur rétroéclairé (meilleure lisibilité), pédale de remise à zéro, durée de batterie optimisée, taille de mémoire augmentée à 500 valeurs, compteur d'animaux, port USB (transfert de données/charge)

                    [thumb] => 
                    [img_empty] => /var/www/vhosts/de3310.ispfr.net/preprod.bioseb.com/modules/prestablog/views/img/product_link_white.jpg
                    [image_presente] => 1
                    [link] => https://preprod.bioseb.com/fr/activite-systeme-moteur-coordination/48-grip-strength-test.html
                )

        )

)
1