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Dernière publication 01/10/2023

Omentin-1 ameliorates the progress of osteoarthritis by promoting IL-4-dependent

Osteoarthritis (OA) is a prevalent joint disease commonly associated with aging and obesity, which can lead to pain, stiffness, joint dysfunction,...

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    [title] => Omentin-1 ameliorates the progress of osteoarthritis by promoting IL-4-dependent
    [paragraph] => Omentin-1 ameliorates the progress of osteoarthritis by promoting IL-4-dependent anti-inflammatory responses and M2 macrophage polarization
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Authors
Ko CY, Lin YY, Achudhan D, Chang JW, Liu SC, Lai CY, Huang YL, Tsai CH, Fong YC

 Lab
China Medical University, Taichung, Taiwan
Journal
Int J Biol Sci 
Abstract
Osteoarthritis (OA) is a prevalent joint disease commonly associated with aging and obesity, which can lead to pain, stiffness, joint dysfunction, and disability. Omentin-1 (also called intelectin-1) is a newly discovered adipokine, which plays a protective role in suppressing the secretion of pro-inflammatory cytokines. Based on data from the Gene Expression Omnibus (GEO) dataset and clinical samples obtained at our institution revealed, determined that omentin-1 and IL-4 (an anti-inflammatory cytokine) levels were significantly lower in OA patients than in normal controls. Omentin-1 was shown to induce IL-4-depedent anti-inflammatory responses and M2 macrophage polarization in OA synovial fibroblasts via the PI3K, ERK, and AMPK pathways. Administering omentin-1 was shown to block cartilage degradation and bone erosion resulting from anterior cruciate ligament transection by inhibiting the production of pro-inflammatory cytokines and promoting M2 macrophage polarization in vivo. Our findings indicate omentin-1 as a promising therapeutic avenue for the treatment for OA.
BIOSEB Instruments Used
Static Weight Bearing Touch: Incapacitance Test (BIO-SWB-TOUCH-M)
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Test non douloureux pour mesurer le niveau d'inconfort (incapacitance) de petits animaux comme les rats et les souris via leur équilibre postural - indépendamment de l'opérateur. Le test de distribution pondérale statique est l'instrument idéal pour vos recherches en nociception et analgésie impliquant des rongeurs: arthrose, dégénération du cartilage, modèles d'inflammation, modèles de traumatismes nerveux , et bien plus... Notre nouveau SWB-Touch inclue désormais un tout nouvel écran tactile!

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