Publications

Dernière publication 28/04/2008

Nefopam and ketoprofen synergy in rodent models of antinociception-

Combinations of analgesics with different mechanisms of action offer the possibility of efficient analgesia with a decrease in side effects as a...

Array
(
    [id_prestablog_news] => 158
    [id_shop] => 1
    [date] => 2008-04-28 00:00:00
    [date_modification] => 2024-02-09 14:15:11
    [langues] => ["1","2"]
    [actif] => 1
    [slide] => 0
    [url_redirect] => 
    [average_rating] => 
    [number_rating] => 
    [author_id] => 1
    [featured] => 0
    [prim_key] => 314
    [id_lang] => 2
    [title] => Nefopam and ketoprofen synergy in rodent models of antinociception-
    [paragraph] => Nefopam and ketoprofen synergy in rodent models of antinociception.
    [content] => 
Authors
P. Girard, D. Verniers, M.-C. Coppé, Y. Pansart, J.-M. Gillardin.

 Lab
Biocodex, Service de Pharmacologie, Compiègne, France.
Journal
European Journal of Pharmacology
Abstract
Combinations of analgesics with different mechanisms of action offer the possibility of efficient analgesia with a decrease in side effects as a result of reduced dosages of one or both compounds. Based on a clinical observation of synergism between nefopam, a centrally acting non-opioid that inhibits monoamines reuptake, and ketoprofen, a non-steroidal anti-inflammatory drug, the objective of this study was to further explore this antinociceptive synergy in four distinct animal models of pain (both drugs were administered subcutaneously). Strong antinociceptive properties were observed in the mouse writhing abdominal test with ED50 values of 2.56 ± 0.38 and 1.41 ± 0.41 mg/kg for nefopam and ketoprofen, respectively. In the inflammatory phase of the mouse formalin test, both compounds significantly inhibited the licking time of the injected hind-paw with ED50 of 4.32 ± 0.17 mg/kg for nefopam and 49.56 ± 15.81 mg/kg for ketoprofen. Isobolographic analysis revealed that this drug combination is synergistic in the formalin test and additive in the writhing test. In rat carrageenan-induced tactile allodynia, single administration of nefopam or ketoprofen only partially reduced allodynia. Combination of low analgesic doses of nefopam (10 or 30 mg/kg) with low analgesic doses of ketoprofen (30 or 100 mg/kg) significantly reduced or reversed allodynia, with a more pronounced anti-allodynic effect and a longer duration efficacy. In a rat model of postoperative thermal hyperalgesia induced by incision, co-administration of nefopam at a low analgesic dose (10 mg/kg) with ketoprofen at non-analgesic doses (30 or 100 mg/kg) showed the appearance of a strong anti-hyperalgesic effect, maintained during at least 3 h. In conclusion, co-administration of nefopam with ketoprofen is synergistic, and should allow either to increase their analgesic efficacy and/or to reduce their side effects.
BIOSEB Instruments Used
SMALGO: SMall animal ALGOmeter (BIO-SMALGO)
    [meta_description] => 
    [meta_keywords] => http://www.sciencedirect.com/science/article/pii/S0014299908001593
    [meta_title] => 
    [link_rewrite] => nefopam-and-ketoprofen-synergy-in-rodent-models-of-antinociception-
    [actif_langue] => 1
    [read] => 1249
    [count_comments] => 0
    [id] => 158
    [categories] => Array
        (
            [36] => Array
                (
                    [id_prestablog_categorie] => 36
                    [title] => Allodynie mécanique & Hyperalgésie
                    [link_rewrite] => Allodynie-mecanique-Hyperalgesie
                )

            [10] => Array
                (
                    [id_prestablog_categorie] => 10
                    [title] => Douleur
                    [link_rewrite] => Douleur
                )

            [28] => Array
                (
                    [id_prestablog_categorie] => 28
                    [title] => Douleurs inflammatoires
                    [link_rewrite] => Douleurs-inflammatoires
                )

            [33] => Array
                (
                    [id_prestablog_categorie] => 33
                    [title] => Douleurs post-opératoires
                    [link_rewrite] => Douleurs-post-opératoires
                )

            [2] => Array
                (
                    [id_prestablog_categorie] => 2
                    [title] => Publications
                    [link_rewrite] => publications
                )

        )

    [authors] => 
    [paragraph_crop] => Nefopam and ketoprofen synergy in rodent models of antinociception.
    [link_for_unique] => 1
    [products_liaison] => Array
        (
            [1207] => Array
                (
                    [name] => SMALGO: Analgésimètre pour petits animaux - Sans fil
                    [description_short] => 
Dédié aux petits animaux tels que les rats et les souris, le Smalgo est un algomètre (ou analgésimètre) à pression conçu pour faciliter l'évaluation de seuils de sensibilité. Il s'agit d'un outil indispensable pour les études sur l'arthrose et la douleur. Un instrument rapide, facile d'utilisation et fiable pour évaluer le seuil de sensibilité à la douleur chez l'animal par l'application d'une force progressive, qui peut également être utilisé pour le screening de substances pharmacologiques, le phénotypage, ainsi que les études sur les neuropathies, les inflammations et les douleurs post-opératoires. Maintenant en version sans-fil, pour être libéré des câbles!

                    [thumb] => 
                    [img_empty] => /var/www/vhosts/de3310.ispfr.net/preprod.bioseb.com/modules/prestablog/views/img/product_link_white.jpg
                    [image_presente] => 1
                    [link] => https://preprod.bioseb.com/fr/douleur-allodyniehyperalgesie-mecanique/1207-smalgo-small-animal-algometer.html
                )

        )

)
1