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Dernière publication 31/01/2016

Functional characterization of a mouse model for central post-stroke pain

Stroke patients often suffer from a central neuropathic pain syndrome called central post-stroke pain. This syndrome is characterized by evoked...

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    [title] => Functional characterization of a mouse model for central post-stroke pain
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Authors
Simon Gritsch, MD Kiran Kumar Bali, PhD Rohini Kuner, Ph Daniel Vardeh, MD



 Lab
Institute for Pharmacology, University of Heidelberg, Heidelberg, Germany


Journal
Mol Pain


Abstract
 Stroke patients often suffer from a central neuropathic pain syndrome called central post-stroke pain. This syndrome is characterized by evoked pain hypersensitivity as well as spontaneous, on-going pain in the body area affected by the stroke. Clinical evidence strongly suggests a dysfunction in central pain pathways as an important pathophysiological factor in the development of central post-stroke pain, but the exact underlying mechanisms remain poorly understood. To elucidate the underlying pathophysiology of central post-stroke pain, we generated a mouse model that is based on a unilateral stereotactic lesion of the thalamic ventral posterolateral nucleus, which typically causes central post-stroke pain in humans.
BIOSEB Instruments Used
Cold Hot Plate Test (BIO-CHP)

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Instrument de test de la sensibilité de l'animal à la douleur résultant de l'exposition à la chaleur ou au froid: la plaque froid et chaud de Bioseb est un instrument innovant ouvrant de nouveaux champs d'investigation pour vos recherches en analgésie et nociception, et un outil efficace pour le screening de substances analgésiques basé sur les modèles de rat ou souris.


Instrument for ratsInstrument for mice

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