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Dernière publication 01/09/2021

Inhibition of endothelin A receptor by a novel- selective receptor antagonist en

The misuse of opioids has led to an epidemic in recent times. The endothelin A receptor (ETAR) has recently attracted attention as a novel...

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    [title] => Inhibition of endothelin A receptor by a novel- selective receptor antagonist en
    [paragraph] => Inhibition of endothelin A receptor by a novel- selective receptor antagonist enhances morphine-induced analgesia- Possible functional interaction of dimerized endothelin A and mu-opioid receptors
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Authors
Y Kurodaab,M Nonakab, Y Kamikubo et al



 Lab
The Jikei University School of Medicine, Minato-ku, Tokyo, Japan.


Journal
Biomedicine & Pharmacotherapy


Abstract
The misuse of opioids has led to an epidemic in recent times. The endothelin A receptor (ETAR) has recently attracted attention as a novel therapeutic target to enhance opioid analgesia. We hypothesized that endothelin A receptors may affect pain mechanisms by heterodimerization with mu-opioid receptors. We examined the mechanisms of ETAR-mediated pain and the potential therapeutic effects of an ETAR antagonist, Compound-E, as an agent for analgesia.
BIOSEB Instruments Used
Rodent pincher - analgesia meter (BIO-RP-M)

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Un algomètre rapide et précis, basé sur une pince instrumentée: une alternative au test de Randall-Selitto. Ce nouvel algésimètre développé par Bioseb selon Luis-Delgado et al. (2005) permet des tests nociceptifs précis et la mesure du seuil de douleur mécanique sur pattes de rats ou de souris, avec une contrainte minimale. Maintenant en version sans-fil, pour être libéré des câbles!


Instrument for ratsInstrument for mice

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