Publications

Dernière publication 01/08/2010

Effect of sildenafil on the anticonvulsant action of classical and second-genera

PURPOSE: The goal of the present study was to evaluate the effects of sildenafil on the threshold for electrically induced seizures in mice. In...

Array
(
    [id_prestablog_news] => 268
    [id_shop] => 1
    [date] => 2010-08-01 00:00:00
    [date_modification] => 2024-02-09 14:15:11
    [langues] => ["1","2"]
    [actif] => 1
    [slide] => 0
    [url_redirect] => 
    [average_rating] => 
    [number_rating] => 
    [author_id] => 1
    [featured] => 0
    [prim_key] => 534
    [id_lang] => 2
    [title] => Effect of sildenafil on the anticonvulsant action of classical and second-genera
    [paragraph] => Effect of sildenafil on the anticonvulsant action of classical and second-generation antiepileptic drugs in maximal electroshock-induced seizures in mice. 
    [content] => 
Authors
D. Nieoczym, J. _uszczki, S. Czuczwar, P. Wlaz. 

 Lab
Maria Curie-Sk_odowska University, Institute of Biology, Department of Animal Physiology, Lublin, Poland.
Journal
Epilepsia
Abstract
PURPOSE: The goal of the present study was to evaluate the effects of sildenafil on the threshold for electrically induced seizures in mice. In addition, interactions between sildenafil and classical and second-generation antiepileptic drugs (AEDs), that is, carbamazepine (CBZ), phenobarbital (PB), phenytoin (PHT), valproate (VPA), lamotrigine (LTG), topiramate (TPM), and oxcarbazepine (OXC) were evaluated.  METHODS: Two electroconvulsive tests were used: maximal electroshock seizure threshold (MEST) and maximal electroshock seizure (MES) tests in mice. Acute adverse effects of the studied combinations were investigated in the chimney test, step-through passive avoidance task, and grip-strength test. Total brain and free plasma concentrations of AEDs were also determined. RESULTS: Sildenafil raised the threshold for electroconvulsions in a dose-dependent manner. It also increased the anticonvulsant activity of CBZ, VPA, and TPM in the MES test, whereas the activity of the remaining AEDs was not significantly changed. Sildenafil increased total brain and free (protein unbound) plasma CBZ concentrations and total brain VPA concentration. Neither sildenafil nor its coadministration with the studied AEDs affected motor coordination and long-term memory in mice. Interestingly, sildenafil dose-dependently enhanced the skeletal muscle strength in mice, although combinations of sildenafil with AEDs were ineffective in this respect. CONCLUSIONS: Sildenafil significantly raised the threshold for electroconvulsions in mice without any impairment of motor performance and long-term memory, but it enhanced muscle strength. Treatment of patients on CBZ or VPA with sildenafil may not be recommended due to pharmacokinetic interactions. Coadministration of sildenafil with other AEDs, especially with TPM, seems to be a reasonable choice.
BIOSEB Instruments Used
Grip strength test (BIO-GS3)
    [meta_description] => 
    [meta_keywords] => http://onlinelibrary.wiley.com/doi/10.1111/j.1528-1167.2009.02485.x/abstract;jsessionid=C1ED4B84F6B5C2293C790AE7E2282734.d01t01
    [meta_title] => 
    [link_rewrite] => effect-of-sildenafil-on-the-anticonvulsant-action-of-classical-and-second-generation-antiepileptic-drugs-in-maximal-electroshock-induced-seizures-in-mice--
    [actif_langue] => 1
    [read] => 822
    [count_comments] => 0
    [id] => 268
    [categories] => Array
        (
            [41] => Array
                (
                    [id_prestablog_categorie] => 41
                    [title] => Épilepsie
                    [link_rewrite] => Épilepsie
                )

            [2] => Array
                (
                    [id_prestablog_categorie] => 2
                    [title] => Publications
                    [link_rewrite] => publications
                )

            [11] => Array
                (
                    [id_prestablog_categorie] => 11
                    [title] => Système Nerveux Central (SNC)
                    [link_rewrite] => Systeme-Nerveux-Central-SNC
                )

        )

    [authors] => 
    [paragraph_crop] => Effect of sildenafil on the anticonvulsant action of classical and second-generation [...]
    [link_for_unique] => 1
    [products_liaison] => Array
        (
            [48] => Array
                (
                    [name] => Test d'agrippement
                    [description_short] => 
Une méthode simple pour quantifier objectivement la force musculaire des rats et souris et l'effet de drogues, toxines, maladies musculaires (ex: myopathie) et neurodégénératives. Cette mesure de force est souvent employée en association avec le test de coordination motrice ROTAROD: un sujet présentant une coordination normale montrera des résultats médiocres en cas de faible force musculaire. Un must pour vos recherches sur l'activité, la coordination et le contrôle musculaire: particulièrement utile pour vos études sur les maladies de Parkinson et Huntington.
Nouveautés GS4 - 2023: Écran couleur rétroéclairé (meilleure lisibilité), pédale de remise à zéro, durée de batterie optimisée, taille de mémoire augmentée à 500 valeurs, compteur d'animaux, port USB (transfert de données/charge)

                    [thumb] => 
                    [img_empty] => /var/www/vhosts/de3310.ispfr.net/preprod.bioseb.com/modules/prestablog/views/img/product_link_white.jpg
                    [image_presente] => 1
                    [link] => https://preprod.bioseb.com/fr/activite-systeme-moteur-coordination/48-grip-strength-test.html
                )

        )

)
1