Publications

Dernière publication 15/12/2011

T-bet deficient mice exhibit resistance to stress-induced development of depress

T-bet, a Th1-specific T-box transcription factor, regulates Th1 development by inducing endogenous Th1 cytokines and IFN-_. This study was...

Array
(
    [id_prestablog_news] => 363
    [id_shop] => 1
    [date] => 2011-12-15 00:00:00
    [date_modification] => 2024-02-09 14:15:11
    [langues] => ["1","2"]
    [actif] => 1
    [slide] => 0
    [url_redirect] => 
    [average_rating] => 
    [number_rating] => 
    [author_id] => 1
    [featured] => 0
    [prim_key] => 722
    [id_lang] => 2
    [title] => T-bet deficient mice exhibit resistance to stress-induced development of depress
    [paragraph] => T-bet deficient mice exhibit resistance to stress-induced development of depression-like behaviors. 
    [content] => 
Authors
S.-J. Kim, H. Lee, H.-Y. Joung, G. Lee, H.-J. Lee et al. 

 Lab
Kyung-Hee University, College of Oriental Medicine, Department of Physiology, Seoul, Republic of Korea.
Journal
Journal of NeuroImmunology
Abstract
T-bet, a Th1-specific T-box transcription factor, regulates Th1 development by inducing endogenous Th1 cytokines and IFN-_. This study was conducted to determine if T-bet knockout mice exhibit resistance to stress-induced development of depression-like behaviors. The T-bet knockout mice significantly reduced depressive-like behaviors provoked by repeated restraint stress in an elevated plus-maze test (EPM), tail suspension test (TST), and forced swim test (FST). Moreover, stress-induced elevations of the pro-inflammatory cytokines were attenuated in T-bet deficient group. These results suggest that T-bet directly mediated stress-induced depression. Therefore, understanding T-bet function during stress represents an additional treatment strategy for depression.
BIOSEB Instruments Used
Tail Suspension Test - Wireless (BIO-TST5)
    [meta_description] => 
    [meta_keywords] => http://www.jni-journal.com/article/S0165-5728%2811%2900261-X/abstract
    [meta_title] => 
    [link_rewrite] => t-bet-deficient-mice-exhibit-resistance-to-stress-induced-development-of-depression-like-behaviors--
    [actif_langue] => 1
    [read] => 987
    [count_comments] => 0
    [id] => 363
    [categories] => Array
        (
            [57] => Array
                (
                    [id_prestablog_categorie] => 57
                    [title] => Dépression
                    [link_rewrite] => Depression
                )

            [2] => Array
                (
                    [id_prestablog_categorie] => 2
                    [title] => Publications
                    [link_rewrite] => publications
                )

            [58] => Array
                (
                    [id_prestablog_categorie] => 58
                    [title] => Stress
                    [link_rewrite] => Stress
                )

            [15] => Array
                (
                    [id_prestablog_categorie] => 15
                    [title] => Troubles de l'humeur
                    [link_rewrite] => Troubles-de-l-humeur
                )

        )

    [authors] => 
    [paragraph_crop] => T-bet deficient mice exhibit resistance to stress-induced development of depression-like behaviors. 
    [link_for_unique] => 1
    [products_liaison] => Array
        (
            [2] => Array
                (
                    [name] => Test de suspension caudale automatique- Sans-fil
                    [description_short] => 
La version 5 du Test de Suspension Caudale de Bioseb, basée sur des capteurs de force ainsi que sur de l'acquisition vidéo, est la seule et unique solution totalement automatisée au monde pour effectuer un test de désespoir comportemental simple et objectif sur souris. Il s'agit d'une méthode rapide, fiable et sans douleur pour tester les effets psychotropes de drogues et substances comme les antidépresseurs et les sédatifs. Ce test classique et indolore pour la recherche sur l'anxiété et la dépression est désormais présenté avec un nouveau logiciel puissant et moderne, dans une version sans-fil BlueTooth.

                    [thumb] => 
                    [img_empty] => /var/www/vhosts/de3310.ispfr.net/preprod.bioseb.com/modules/prestablog/views/img/product_link_white.jpg
                    [image_presente] => 1
                    [link] => https://preprod.bioseb.com/fr/anxiete-depression/2-tail-suspension-test-wireless.html
                )

        )

)
1