Publications

Dernière publication 01/12/2007

Effects of early postnatal hypernutrition on nephron number and long-term renal

Various antenatal events impair nephrogenesis in humans as well as in several animal models. The consecutive low nephron endowment may contribute...

Array
(
    [id_prestablog_news] => 131
    [id_shop] => 1
    [date] => 2007-12-01 00:00:00
    [date_modification] => 2024-02-09 14:15:11
    [langues] => ["1","2"]
    [actif] => 1
    [slide] => 0
    [url_redirect] => 
    [average_rating] => 
    [number_rating] => 
    [author_id] => 1
    [featured] => 0
    [prim_key] => 260
    [id_lang] => 2
    [title] => Effects of early postnatal hypernutrition on nephron number and long-term renal 
    [paragraph] => Effects of early postnatal hypernutrition on nephron number and long-term renal function and structure in rats.
    [content] => 
Authors
F. Boubred, C. Buffat, J.-M. Feuerstein, L. Daniel, M. Tsimaratos et al.

 Lab
Université de la Méditerranée, Faculté de Médecine, UPRES EA 2193, Marseille, France.
Journal
American Journal of Renal Physiology
Abstract
Various antenatal events impair nephrogenesis in humans as well as in several animal models. The consecutive low nephron endowment may contribute to an increased risk for cardiovascular and renal diseases in adulthood. However, little knowledge is available on the influence of the postnatal environment, especially nutrition, on nephrogenesis. Moreover, the consequences of early postnatal nutrition in late adulthood are not clear. We used a model of early postnatal overfeeding (OF) induced by reduction of litter size (3 pups/litter) in rats. Systolic blood pressure (SBP; plethysmography), glomerular filtration rate (clearance of creatinine), glomerular number and volume, and glomerulosclerosis were evaluated in 22-mo-old aging offspring. Early postnatal OF was associated with increased weight gain during the suckling period (+40%, P < 0.01) and a 20% increase in glomerular number (P < 0.05). However, an increase in SBP at 12 mo by an average of 18 mmHg and an increase in proteinuria (2.6-fold) and glomerulosclerosis at 22 mo of age were observed in OF male offspring compared with controls. In conclusion, early postnatal OF in the rat enhances postnatal nephrogenesis, but elevated blood pressure and glomerulosclerosis are still observed in male adults. Factors other than glomerular number reduction are likely to contribute to the arterial hypertension induced by early postnatal OF.
BIOSEB Instruments Used
Non Invasive Pressure Measurement (LE5001),Cuffs and pulse transducers for LE 500X indirect blood pressure meters (LE5012)
    [meta_description] => 
    [meta_keywords] => http://ajprenal.physiology.org/content/293/6/F1944.short
    [meta_title] => 
    [link_rewrite] => effects-of-early-postnatal-hypernutrition-on-nephron-number-and-long-term-renal-function-and-structure-in-rats-
    [actif_langue] => 1
    [read] => 708
    [count_comments] => 0
    [id] => 131
    [categories] => Array
        (
            [26] => Array
                (
                    [id_prestablog_categorie] => 26
                    [title] => Domaines de recherche divers
                    [link_rewrite] => Domaines-de-recherche-divers
                )

            [2] => Array
                (
                    [id_prestablog_categorie] => 2
                    [title] => Publications
                    [link_rewrite] => publications
                )

        )

    [authors] => 
    [paragraph_crop] => Effects of early postnatal hypernutrition on nephron number and long-term renal function and [...]
    [link_for_unique] => 1
    [products_liaison] => Array
        (
            [8] => Array
                (
                    [name] => Mesure de pression non invasive
                    [description_short] => Technique simple et fiable pour mesurer la pression artérielle systémique et 
les paramètres cardiovasculaires chez les rongeurs sans cathétérisme invasif
                    [thumb] => 
                    [img_empty] => /var/www/vhosts/de3310.ispfr.net/preprod.bioseb.com/modules/prestablog/views/img/product_link_white.jpg
                    [image_presente] => 1
                    [link] => https://preprod.bioseb.com/fr/physiologie-recherche-respiratoire/8-non-invasive-pressure-measurement.html
                )

            [1223] => Array
                (
                    [name] => Brassards de pression et Détecteurs de pouls
                    [description_short] => Pour enregistreur de pression artérielle LE 500X
                    [thumb] => 
                    [img_empty] => /var/www/vhosts/de3310.ispfr.net/preprod.bioseb.com/modules/prestablog/views/img/product_link_white.jpg
                    [image_presente] => 1
                    [link] => https://preprod.bioseb.com/fr/physiologie-recherche-respiratoire/1223-cuffs-and-pulse-transducers-for-le-500x-indirect-blood-pressure-meters.html
                )

        )

)
1