Stress - Publications Scientifiques

Dernière publication 10/01/2022

Neuronal Yin Yang1 in the prefrontal cortex regulates transcriptional and behavi

Although the synaptic alterations associated with the stress-related mood disorder major depression has been well-documented, the underlying...

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    [title] => Neuronal Yin Yang1 in the prefrontal cortex regulates transcriptional and behavi
    [paragraph] => Neuronal Yin Yang1 in the prefrontal cortex regulates transcriptional and behavioral responses to chronic stress in mice
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Authors
DY Kwon, B Xu, P Hu et al

 Lab
Department of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA
Journal
Nature Communications
Abstract
Although the synaptic alterations associated with the stress-related mood disorder major depression has been well-documented, the underlying transcriptional mechanisms remain poorly understood. Here, we perform complementary bulk nuclei- and single-nucleus transcriptome profiling and map locus-specific chromatin interactions in mouse neocortex to identify the cell type-specific transcriptional changes associated with stress-induced behavioral maladaptation. We find that cortical excitatory neurons, layer 2/3 neurons in particular, are vulnerable to chronic stress and acquire signatures of gene transcription and chromatin structure associated with reduced neuronal activity and expression of Yin Yang 1 (YY1). Selective ablation of YY1 in cortical excitatory neurons enhances stress sensitivity in both male and female mice and alters the expression of stress-associated genes following an abbreviated stress exposure. These findings demonstrate how chronic stress impacts transcription in cortical excitatory neurons and identify YY1 as a regulator of stress-induced maladaptive behavior in mice.
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