Prise de décision - Publications Scientifiques

Dernière publication 01/04/2024

Thermal escape box- A cost-benefit evaluation paradigm for investigating thermos

Thermosensation, the ability to detect and estimate temperature, is an evolutionarily conserved process that is essential for survival....

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    [title] => Thermal escape box- A cost-benefit evaluation paradigm for investigating thermos
    [paragraph] => Thermal escape box- A cost-benefit evaluation paradigm for investigating thermosensation and thermal pain
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Authors
Dayton JR, Marquez J, Romo AK, Chen YJ, Contreras JE, Griffith TN

Lab
University of California, Davis. Department of Pharmacology, 1275 Med Science Drive, Davis, CA 95616, United States.
Journal
Neurobiol Pain
Abstract
Thermosensation, the ability to detect and estimate temperature, is an evolutionarily conserved process that is essential for survival. Thermosensing is impaired in various pain syndromes, resulting in thermal allodynia, the perception of an innocuous temperature as painful, or thermal hyperalgesia, an exacerbated perception of a painful thermal stimulus. Several behavioral assays exist to study thermosensation and thermal pain in rodents, however, most rely on reflexive withdrawal responses or the subjective quantification of spontaneous nocifensive behaviors. Here, we created a new apparatus, the thermal escape box, which can be attached to temperature-controlled plates and used to assess temperature-dependent effort-based decision-making. The apparatus consists of a light chamber with an opening that fits around temperature-controlled plates, and a small entryway into a dark chamber. A mouse must choose to stay in a brightly lit aversive area or traverse the plates to escape to the enclosed dark chamber. We quantified escape latencies of adult C57Bl/6 mice at different plate temperatures from video recordings and found they were significantly longer at 5 °C, 18 °C, and 52 °C, compared to 30 °C, a mouse's preferred ambient temperature. Differences in escape latencies were abolished in male Trpm8-/- mice and in male Trpv1-/- animals. Finally, we show that chronic constriction injury procedures or oxaliplatin treatement significantly increased escape latencies at cold temperatures compared to controls, the later of which was prevented by the analgesic meloxicam. This demonstrates the utility of this assay in detecting cold pain. Collectively, our study has identified a new and effective tool that uses cost-benefit valuations to study thermosensation and thermal pain.
BIOSEB Instruments Used
Thermal Place Preference- 2 Temperatures Choice Nociception Test (BIO-T2CT)
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Un test indépendant de l'opérateur pour étudier les seuils de douleur chez les rongeurs (rats et souris) par l'évaluation de la préférence de température (zone de confort thermal) - un outil innovant pour vos recherches sur l'analgésie et la nociception, ouvrant de nouveaux champs d'étude, et une solution idéale pour le screening de médicaments analgésiques et nociceptifs. Désormais fourni avec un nouveau logiciel dernier cri permettant de monitorer l'activité et les transitions de température rapides!

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Grâce à ces kits, il est possible de combiner dans un même dispositif :

une double aversion : contextuelle (lumière / obscurité, motifs visuels) et thermique,
un paradigme de préférence conditionnée (CPP)



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