Métabolisme - Publications Scientifiques

Dernière publication 16/04/2020

Short_and long_term administration of imeglimin counters cardiorenal dysfunction

Introduction Imeglimin, a glucose_lowering agent targeting mitochondrial bioenergetics, decreases reactive oxygen species (ROS) overproduction and...

Array
(
    [id_prestablog_news] => 1261
    [id_shop] => 1
    [date] => 2020-04-16 00:00:00
    [date_modification] => 2024-02-09 14:15:12
    [langues] => ["1","2"]
    [actif] => 1
    [slide] => 0
    [url_redirect] => 
    [average_rating] => 
    [number_rating] => 
    [author_id] => 1
    [featured] => 0
    [prim_key] => 2480
    [id_lang] => 2
    [title] => Short_and long_term administration of imeglimin counters cardiorenal dysfunction
    [paragraph] => Short_and long_term administration of imeglimin counters cardiorenal dysfunction in a rat model of metabolic syndrome
    [content] => 
Authors
M Lachaux, M Souli

 Lab
INSERM U1096, UFR de Sant
Journal
Endochrinology, Diabetes and Metabolism
Abstract
IntroductionImeglimin, a glucose_lowering agent targeting mitochondrial bioenergetics, decreases reactive oxygen species (ROS) overproduction and improves glucose homeostasis. We investigated whether this is associated with protective effects on metabolic syndrome_related left ventricular (LV) and vascular dysfunctions.
Methods We used Zucker fa/fa  rats to assess the effects on LV function, LV tissue perfusion, LV oxidative stress and vascular function induced by imeglimin administered orally for 9 or 90 days at a dose of 150 mg/kg twice daily. 
Results Compared to untreated animals, 9_ and 90_day imeglimin treatment decreased LV end_diastolic pressure and LV end_diastolic pressure_volume relation, increased LV tissue perfusion and decreased LV ROS production. Simultaneously, imeglimin restored acetylcholine_mediated coronary relaxation and mesenteric flow_mediated dilation. One hour after imeglimin administration, when glucose plasma levels were not yet modified, imeglimin reduced LV mitochondrial ROS production and improved LV function. Ninety_day imeglimin treatment reduced related LV and kidney fibrosis and improved kidney function.
Conclusion In a rat model, mimicking Human metabolic syndrome, imeglimin immediately countered metabolic syndrome_related cardiac diastolic and vascular dysfunction by reducing oxidative stress/increased NO bioavailability and improving myocardial perfusion and after 90_day treatment myocardial and kidney structure, effects that are, at least in part, independent from glucose control.
BIOSEB Instruments Used
Treadmill (BX-TM),Passive avoidance (LE870)
    [meta_description] => 
    [meta_keywords] => https://onlinelibrary.wiley.com/doi/full/10.1002/edm2.128
    [meta_title] => 
    [link_rewrite] => shortand-longterm-administration-of-imeglimin-counters-cardiorenal-dysfunction-in-a-rat-model-of-metabolic-syndrome
    [actif_langue] => 1
    [read] => 1113
    [count_comments] => 0
    [id] => 1261
    [categories] => Array
        (
            [100] => Array
                (
                    [id_prestablog_categorie] => 100
                    [title] => Fonction cardiaque
                    [link_rewrite] => Fonction-cardiaque
                )

            [23] => Array
                (
                    [id_prestablog_categorie] => 23
                    [title] => Métabolisme
                    [link_rewrite] => Metabolisme
                )

            [77] => Array
                (
                    [id_prestablog_categorie] => 77
                    [title] => Métabolisme général
                    [link_rewrite] => Metabolisme-general
                )

            [2] => Array
                (
                    [id_prestablog_categorie] => 2
                    [title] => Publications
                    [link_rewrite] => publications
                )

        )

    [authors] => 
    [paragraph_crop] => Short_and long_term administration of imeglimin counters cardiorenal dysfunction in a rat [...]
    [link_for_unique] => 1
    [products_liaison] => Array
        (
            [61] => Array
                (
                    [name] => Tapis roulant
                    [description_short] => 
Conçu pour les études sur l'entraînement physique et la fatigue chez les rongeurs - et désormais livré avec un tout nouvel écran tactile sur la console de commande.
                    [thumb] => 
                    [img_empty] => /var/www/vhosts/de3310.ispfr.net/preprod.bioseb.com/modules/prestablog/views/img/product_link_white.jpg
                    [image_presente] => 1
                    [link] => https://preprod.bioseb.com/fr/activite-systeme-moteur-coordination/61-treadmill.html
                )

            [519] => Array
                (
                    [name] => Évitement passif
                    [description_short] => Test de motivation par la peur, classiquement utilisé 
pour évaluer la mémoire à long ou court terme 
sur de petits animaux de laboratoire
                    [thumb] => 
                    [img_empty] => /var/www/vhosts/de3310.ispfr.net/preprod.bioseb.com/modules/prestablog/views/img/product_link_white.jpg
                    [image_presente] => 1
                    [link] => https://preprod.bioseb.com/fr/apprentissagememoire-attention-addiction/519-passive-avoidance.html
                )

        )

)
1