Système musculaire - Publications Scientifiques

Dernière publication 18/02/2020

Nutritional intervention with cyanidin hinders the progression of muscular dystr

Muscular Dystrophies are severe genetic diseases due to mutations in structural genes, characterized by progressive muscle wasting that compromises...

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    [title] => Nutritional intervention with cyanidin hinders the progression of muscular dystr
    [paragraph] => Nutritional intervention with cyanidin hinders the progression of muscular dystrophy
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Authors
M Saclier, C Bonfanti, S Antonini, G Angelini, G Mura

 Lab
Department of Biosciences, University of Milan, Milan, Italy
Journal
Cell Death & Disease
Abstract
Muscular Dystrophies are severe genetic diseases due to mutations in structural genes, characterized by progressive muscle wasting that compromises patients’ mobility and respiratory functions. Literature underlined oxidative stress and inflammation as key drivers of these pathologies. Interestingly among different myofiber classes, type I fibers display a milder dystrophic phenotype showing increased oxidative metabolism. This work shows the benefits of a cyanidin-enriched diet, that promotes muscle fiber-type switch and reduced inflammation in dystrophic alpha-sarcoglyan (Sgca) null mice having, as a net outcome, morphological and functional rescue. Notably, this benefit is achieved also when the diet is administered in dystrophic animals when the signs of the disease are seriously evident. Our work provides compelling evidence that a cyanidin-rich diet strongly delays the progression of muscular dystrophies, paving the way for a combinatorial approach where nutritional-based reduction of muscle inflammation and oxidative stress facilitate the successful perspectives of definitive treatments.
BIOSEB Instruments Used
Treadmill (BX-TM),Passive avoidance (LE870)
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