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Dernière publication 01/04/2018

Assessment of the effects of exercise on a murine model of OA

International guidelines recommend exercise to delay rapid progression of osteoarthritis (OA). Numerous studies have shown that land-based exercise...

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Authors
C. Huesa, L. Dunning, K. MacDougall, A. Ortiz, M. Villaluz, M. Fegen, A. Crilly, G. Litherland, R. van t Hof, C. Goodyear, J.C. Lockhart


Lab
Univ. of the West of Scotland, Glasgow, United Kingdom

Journal
Osteoarthritis and Cartilage

Abstract
International guidelines recommend exercise to delay rapid progression of osteoarthritis (OA). Numerous studies have shown that land-based exercise regimes, when performed regularly, leads to an improvement in joint mobility and pain. In vivo models of OA mimic many of the parameters of post-traumatic human OA. Destabilization of the medial meniscus (DMM) in rodents results in progressive development of OA with cartilage damage, osteosclerosis, mild synovitis, ligament damage/calcification and osteophyte formation.

BIOSEB Instruments Used
Activmeter (BIO-ACTIV-R)

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Une façon simple pour mesurer l'activité des rongeurs sur plusieurs jours dans leurs cages de vie. Basé uniquement sur l'analyse du poids de l'animal, L'ACTIVMETRE Bioseb permet une mesure précise de l'activité et des déplacements du rongeur (rat et souris), dans toutes les conditions d'éclairage.

fiber_new Possibilité d’ajouter la mesure de l’activité verticale des animaux dans la cage (en option).

Instrument for ratsInstrument for mice

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