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Dernière publication 29/01/2016

Probable involvement of p11 with interferon alpha induced depression

Depression is one of the major side effects of interferon alpha (IFN-α) treatment, but the molecular mechanism underlying IFN-α-induced depression...

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    [title] => Probable involvement of p11 with interferon alpha induced depression
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Authors
Guo J, Zhang W, Zhang L et al.

 Lab
Research Center for Immunology, School of Basic Medical Sciences, Xinxiang Medical University, China
Journal
Sci Rep
Abstract
Depression is one of the major side effects of interferon alpha (IFN-α) treatment, but the molecular mechanism underlying IFN-α-induced depression remains unclear. Several studies have shown that the serotonin receptors 5-HTR1b and 5-HTR4 play key roles in the anti-depression effects associated with p11 (S100A10). We investigated the effects of IFN-α on the regulation of p11, 5-HTR1b and 5-HTR4 in mice and human neuroblastoma cells (SH-sy5y). We found that intraperitoneal injection with IFN-α in Balb/c mice resulted in an increased immobility in FST and TST, and potently lowered the protein levels of p11, 5-HTR1b and 5-HTR4 in the hippocampus or cingulate gyrus. IFN-α significantly down-regulated the protein levels of p11, 5-HTR1b and 5-HTR4 in SH-sy5y cells, in a time- and dose-dependent manner. Our study revealed that over-expression of p11 could prevent the IFN-α-induced down-regulation of 5-HTR1b and 5-HTR4. The results indicated that IFN-α treatment resulted in p11 down-regulation, which subsequently decreased 5-HTR1b and 5-HTR4 in vitro or in vivo. Our findings suggested that p11 might be a potential regulator on 5-HTR1b and 5-HTR4 as well as a predictor of or a therapeutic target for IFN-α-induced depression.
BIOSEB Instruments Used
Tail Suspension Test - Wireless (BIO-TST5),Forced Swimming Test: New FST DUAL SENSOR (BIO-FST-DSM)
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 l'algorithme TYC (Train-Your-Computer) compare les deux sources capteur pour déterminer en temps réel le comportement de l'animal, rendant les résultats complètement indépendants de l'opérateur.

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