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Dernière publication 02/11/2007

Temporal parameters of one-trial tolerance to benzodiazepines in four-plate test

Anxiolytic-like effect of diazepam is abolished by a previous exposure to four-plate test (FPT). Variations of temporal parameters: interval...

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    [title] => Temporal parameters of one-trial tolerance to benzodiazepines in four-plate test
    [paragraph] => Temporal parameters of one-trial tolerance to benzodiazepines in four-plate test–retest.
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Authors
B. Petit-Demouliere, M. Bourin.



 Lab
EA 3256 «Neurobiologie de l’anxiété et de la dépression», Faculté de Médecine, BP 53508, 1 rue Gaston Veil, F44035 Nantes Cedex 01, France


Journal
Behavioural Brain Research


Abstract
Anxiolytic-like effect of diazepam is abolished by a previous exposure to four-plate test (FPT). Variations of temporal parameters: interval between trials and duration of Trial 1, with or without electric punishments allow characterizing factors which are responsible for this loss phenomenon. Complete spatial representation of FPT seems to be responsible of this one-trial tolerance, and needs at least a 30 s exposure to the apparatus to be completed, with or without punishments.
BIOSEB Instruments Used
Aron Test or Four Plates Test (LE830)

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                    [name] => Test d'Aron ou 'Four Plates Test'
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Le 'Four Plates Test' ou test d'Aron est une exclusivité Bioseb!
Un outil rapide pour l'évaluation de substances anxiolytiques putatives chez l'animal naïf. Un "must" pour l'étude de l'anxiété, le screening des drogues et le phénotypage.

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