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Dernière publication 05/10/2019

Highly bioavailable curcumin powder suppresses articular cartilage damage in rat

This study was performed to investigate the effects of highly bioavailable curcumin as Theracurmin (TC) in rats with monosodium iodoacetate...

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    [title] => Highly bioavailable curcumin powder suppresses articular cartilage damage in rat
    [paragraph] => Highly bioavailable curcumin powder suppresses articular cartilage damage in rats with mono-iodoacetate (MIA)-induced osteoarthritis
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Authors
HJ Park, CK Lee, SH Song, JH Yun, A Lee, HJ Park

 Lab
Department of Food and Nutrition, Yuhan University, 590 Gyeongin-ro, Bucheon-si, Gyeonggi-do, 14780, Korea
Journal
Food Science and Biotechnology
Abstract
This study was performed to investigate the effects of highly bioavailable curcumin as Theracurmin (TC) in rats with monosodium iodoacetate (MIA)-induced osteoarthritis (OA). Seventy-seven male Wistar rats were divided into six groups: normal, negative control (MIA only), positive control (Cerebrex), and three experimental groups treated with 500, 1300, or 2600 mg/kg of TC for 5 weeks. MIA injection-induced OA caused 30% weight-bearing imbalance whereas weight bearing imbalance was significantly improved in the TC groups. Mankin scores revealed TC treatment had significantly ameliorated cartilage damage and chondrocyte decrease. The expressions of nitrotyrosine, tumor necrosis factor-alpha, phosphorylated nuclear factor kappa B cells, and cleaved caspase-3 were markedly increased in rat with MIA-induced OA, but the TC-treated groups exhibited a significant reduction in the number of immunoreactive cells in a dose-dependent manner. In conclusion, administration of TC contributes to the anti-arthritic effect in rat with MIA-induced OA.
BIOSEB Instruments Used
Electronic Von Frey 4 (BIO-EVF4)
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Une solution rapide pour déterminer le seuil de sensibilité à la douleur mécanique chez les rongeurs (rats et souris). Maintenant en version sans-fil, pour être libéré des câbles!

Cet instrument électronique précis et simple d'utilisation est le test de référence pour vos recherches en analgésie, nociception, neuropathies et douleurs post-opératoires

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