Publications

Dernière publication 24/01/2012

Huntington's disease knock-in male mice show specific anxiety-like behaviour and

Huntington's disease (HD) is a devastating genetic neurodegenerative disorder. Major depressive disorder and more generally mood disorders are a...

Array
(
    [id_prestablog_news] => 376
    [id_shop] => 1
    [date] => 2012-01-24 00:00:00
    [date_modification] => 2024-02-09 14:15:11
    [langues] => ["1","2"]
    [actif] => 1
    [slide] => 0
    [url_redirect] => 
    [average_rating] => 
    [number_rating] => 
    [author_id] => 1
    [featured] => 0
    [prim_key] => 748
    [id_lang] => 2
    [title] => Huntington's disease knock-in male mice show specific anxiety-like behaviour and
    [paragraph] => Huntington's disease knock-in male mice show specific anxiety-like behaviour and altered neuronal maturation. 
    [content] => 
Authors
S. Orvoen, P. Pla, A. Gardier, F. Saudou, D. David. 

 Lab
Univ Paris-Sud, Faculté de Pharmacie, Châtenay-Malabry, France.
Journal
Neuroscience Letters
Abstract
Huntington's disease (HD) is a devastating genetic neurodegenerative disorder. Major depressive disorder and more generally mood disorders are a major component of the symptoms during the pre-motor symptomatic stages of the disease. We report here that knock-in Hdh(Q111) mice, an animal model of HD, that carry an expanded polyglutamine stretch in the mouse HD protein show an anxio-depressive-like phenotype prior to any impairment of the locomotor function. Strikingly, whereas females develop preferentially a depressive-like behaviour, males had an increased anxiety-like phenotype. Since adult hippocampal neurogenesis has been associated to the pathophysiology and treatment of depression, we investigated whether changes in behavioural phenotypes are associated with proliferation or maturation impairments. Whereas cell proliferation was not affected in knock-in Hdh(Q111) mice, a male-specific marked decrease in late maturation of newborn neurons was observed in the adult dentate gyrus. Together, our results highlight sex differences in both behaviour and adult neurogenesis in a knock-in model of HD.
BIOSEB Instruments Used
Forced Swimming Test: New FST DUAL SENSOR (BIO-FST-DSM)
    [meta_description] => 
    [meta_keywords] => http://www.sciencedirect.com/science/article/pii/S0304394011015850
    [meta_title] => 
    [link_rewrite] => huntingtons-disease-knock-in-male-mice-show-specific-anxiety-like-behaviour-and-altered-neuronal-maturation--
    [actif_langue] => 1
    [read] => 903
    [count_comments] => 0
    [id] => 376
    [categories] => Array
        (
            [57] => Array
                (
                    [id_prestablog_categorie] => 57
                    [title] => Dépression
                    [link_rewrite] => Depression
                )

            [100] => Array
                (
                    [id_prestablog_categorie] => 100
                    [title] => Fonction cardiaque
                    [link_rewrite] => Fonction-cardiaque
                )

            [47] => Array
                (
                    [id_prestablog_categorie] => 47
                    [title] => Maladie de Huntington
                    [link_rewrite] => maladie-de-huntington
                )

            [12] => Array
                (
                    [id_prestablog_categorie] => 12
                    [title] => Neurodégénérescence
                    [link_rewrite] => Neurodegenerescence
                )

            [2] => Array
                (
                    [id_prestablog_categorie] => 2
                    [title] => Publications
                    [link_rewrite] => publications
                )

            [15] => Array
                (
                    [id_prestablog_categorie] => 15
                    [title] => Troubles de l'humeur
                    [link_rewrite] => Troubles-de-l-humeur
                )

        )

    [authors] => 
    [paragraph_crop] => Huntington's disease knock-in male mice show specific anxiety-like behaviour and altered [...]
    [link_for_unique] => 1
    [products_liaison] => Array
        (
            [973] => Array
                (
                    [name] => Test de Nage Forcée: Nouveau FST DUAL SENSOR
                    [description_short] => 
Le nouveau Test de Nage Forcée Bioseb DUAL SENSOR à été développé selon une double approche:
En combinant une double acquisition, vibrations et trace vidéo,
 l'algorithme TYC (Train-Your-Computer) compare les deux sources capteur pour déterminer en temps réel le comportement de l'animal, rendant les résultats complètement indépendants de l'opérateur.

Le gestionnaire d'expériences, le module d'analyse, les possibilités de relecture et l'algorithme TYC sont parmi les fonctionnalités qui font du FST DUAL SENSOR un instrument très innovant et facile d'utilisation pour les études sur rats et souris (jusqu'à 4 animaux à la fois) pour automatiser le test de Porsolt, ou test de désespoir comportemental.

                    [thumb] => 
                    [img_empty] => /var/www/vhosts/de3310.ispfr.net/preprod.bioseb.com/modules/prestablog/views/img/product_link_white.jpg
                    [image_presente] => 1
                    [link] => https://preprod.bioseb.com/fr/anxiete-depression/973-forced-swimming-test-new-fst-dual-sensor.html
                )

        )

)
1