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Dernière publication 01/08/2003

Evidence for an antihyperalgesic effect of venlafaxine in vincristine-induced ne

Venlafaxine, a new antidepressant with fewer side effects, could be of interest to reduce neuropathic pain following antineoplasic drug treatment....

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    [title] => Evidence for an antihyperalgesic effect of venlafaxine in vincristine-induced ne
    [paragraph] => Evidence for an antihyperalgesic effect of venlafaxine in vincristine-induced neuropathy in rat.
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Authors
F. Marchand, A. Alloui, T. Pelissier, A. Hernández, N. Authier et al.



 Lab
Faculté de Médecine, Laboratoire de Pharmacologie Médicale, E 9904 INSERM/UdA, Clermont-Ferrand, France.


Journal
Brain Research


Abstract
Venlafaxine, a new antidepressant with fewer side effects, could be of interest to reduce neuropathic pain following antineoplasic drug treatment. In the present study, we demonstrated that venlafaxine inhibits hyperalgesia in a new rat model of neuropathy induced by the antineoplasic drug vincristine, and exerts its effect preferentially via supraspinal and spinal mechanisms.

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