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Dernière publication 01/08/2019

EFFECT OF 1-HYDROXY-1-1-ETHYLIDENDIPHOSPHONE ACID- BIS-2-PYRIDYL-1-2-4-TRIAZOLYL

The aim of the work is to evaluate the effect of 1-hydroxy-1,1-ethylidenediphosphonic acid, bis(2-pyridyl-1,2,4-triazolyl-3)propane and their...

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    [title] => EFFECT OF 1-HYDROXY-1-1-ETHYLIDENDIPHOSPHONE ACID- BIS-2-PYRIDYL-1-2-4-TRIAZOLYL
    [paragraph] => EFFECT OF 1-HYDROXY-1,1-ETHYLIDENDIPHOSPHONE ACID, BIS(2-PYRIDYL-1,2,4-TRIAZOLYL-3)PROPANE AND THEIR ADDUCT ON THE PAIN SENSITIVITY OF RATS PYRIDYL-1,2,4-TRIAZOLYL-3)PROPANE AND THEIR ADDUCT ON THE PAIN SENSITIVITY OF RATS
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Authors
Cheretaev I. V., Ravaeva M. Yu., Dzheldubaeva E. R, et al


Lab
V. I. Vernadsky Crimean Federal University, Simferopol, Crimea, Russia

Journal
Scientific notes of the Crimean Federal University named after V.I. Vernadsky

Abstract
The aim of the work is to evaluate the effect of 1-hydroxy-1,1-ethylidenediphosphonic acid, bis(2-pyridyl-1,2,4-triazolyl-3)propane and their adduct on the pain sensitivity of male rats in the dose range from 5 to 200 mg/kg.

BIOSEB Instruments Used
Cold Hot Plate Test (BIO-CHP),Rodent pincher - analgesia meter (BIO-RP-M)

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Instrument de test de la sensibilité de l'animal à la douleur résultant de l'exposition à la chaleur ou au froid: la plaque froid et chaud de Bioseb est un instrument innovant ouvrant de nouveaux champs d'investigation pour vos recherches en analgésie et nociception, et un outil efficace pour le screening de substances analgésiques basé sur les modèles de rat ou souris.

Instrument for ratsInstrument for mice

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Un algomètre rapide et précis, basé sur une pince instrumentée: une alternative au test de Randall-Selitto. Ce nouvel algésimètre développé par Bioseb selon Luis-Delgado et al. (2005) permet des tests nociceptifs précis et la mesure du seuil de douleur mécanique sur pattes de rats ou de souris, avec une contrainte minimale. Maintenant en version sans-fil, pour être libéré des câbles!

Instrument for ratsInstrument for mice

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