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Dernière publication 17/07/1015

The anxiolytic-like activity of a novel N-cycloalkyl-N-benzoylpiperazine derivat

Anxiety-related disorders are among the most common mental illnesses in the world for which benzodiazepines, buspirone and antidepressant drugs...

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    [title] => The anxiolytic-like activity of a novel N-cycloalkyl-N-benzoylpiperazine derivat
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Authors
Daniel Jan Struba, Kinga Sa?at, Tadeusz Librowskic, Stanis?aw Lochy?skia, Magdalena Gawe?, Adrian Podkowab



 Lab
Department of Bioorganic Chemistry, Faculty of Chemistry, Wroc?aw University of Technology, Wroc?aw, Poland


Journal
Pharmacological Reports


Abstract
Anxiety-related disorders are among the most common mental illnesses in the world for which benzodiazepines, buspirone and antidepressant drugs remain the first-line treatment. These drugs have good efficacy but they have numerous disadvantages, such as drug abuse potential, delayed onset of action or tolerance. A literature review reveals that a variety of piperazine derivatives may exhibit interesting pharmacological properties, including anxiolytic-like, antidepressant, nootropic and antinociceptive activities demonstrated in animal models, as well as an antioxidant capacity shown in some in vitro tests. Hence, the aim of this study was the synthesis and preliminary pharmacological in vivo evaluation of a novel N-cycloalkyl-N-benzoylpiperazine derivative, compound 9.
BIOSEB Instruments Used
Aron Test or Four Plates Test (LE830)

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Le 'Four Plates Test' ou test d'Aron est une exclusivité Bioseb!
Un outil rapide pour l'évaluation de substances anxiolytiques putatives chez l'animal naïf. Un "must" pour l'étude de l'anxiété, le screening des drogues et le phénotypage.

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