Publications

Dernière publication 30/05/2012

Differential susceptibility to the PPAR-_ agonist pioglitazone in 1-methyl-4-phe

A growing body of evidence suggests that peroxisome proliferator-activated receptor (PPAR) agonists are valuable candidates as disease modifiers in...

Array
(
    [id_prestablog_news] => 401
    [id_shop] => 1
    [date] => 2012-05-30 00:00:00
    [date_modification] => 2024-02-09 14:15:11
    [langues] => ["1","2"]
    [actif] => 1
    [slide] => 0
    [url_redirect] => 
    [average_rating] => 
    [number_rating] => 
    [author_id] => 1
    [featured] => 0
    [prim_key] => 798
    [id_lang] => 2
    [title] => Differential susceptibility to the PPAR-_ agonist pioglitazone in 1-methyl-4-phe
    [paragraph] => Differential susceptibility to the PPAR-_ agonist pioglitazone in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and 6-hydroxydopamine rodent models of Parkinson's disease. 
    [content] => 
Authors
C. Laloux, M. Petrault, C. Lecointe, D. Devos, R. Bordet.

 Lab
Université Lille Nord de France, Faculté de médecine-pôle recherche, Département de Pharmacologie médicale, Lille cedex, France.
Journal
Pharmacological research
Abstract
A growing body of evidence suggests that peroxisome proliferator-activated receptor (PPAR) agonists are valuable candidates as disease modifiers in Parkinson's disease (PD) and may thus enable neuroprotection and preserve motor function. The present study sought to evaluate the effect of the PPAR-gamma agonist pioglitazone in two different animal models of PD. The study was based on nigral dopaminergic neuron labelling and the assessment of motor behaviour in (i) the frequently investigated MPTP mouse model and (ii) the less well-known bilateral 6-OHDA rat model. In MPTP-injected mice, pioglitazone reversed body weight loss and the reduction in rearing frequency and induced significant neuroprotection of the nigrostriatal dopaminergic pathway (by 24%, compared with vehicle). In contrast, pioglitazone did not have any effect on the 73.5% loss of dopaminergic neurons or motor impairments (a reduced rearing frequency and a loss of strength in the forepaws) in bilateral 6-OHDA rats. The PPAR-gamma agonist pioglitazone had a significant neuroprotective effect in MPTP mice but not in bilateral 6-OHDA rats. The various effects of PPAR agonists in both models can be accounted by the different action mechanism of the 2 toxins or by the fact that 3_g 6-OHDA injection was too harmful to be alleviated by the compound. This work supports PPAR-agonists to be relevant in the therapeutic strategy research in Parkinson's disease and highlights the importance in evaluating neuroprotective agent in different models.
BIOSEB Instruments Used
Grip strength test (BIO-GS3)
    [meta_description] => 
    [meta_keywords] => http://www.sciencedirect.com/science/article/pii/S1043661812000321
    [meta_title] => 
    [link_rewrite] => differential-susceptibility-to-the-ppar--agonist-pioglitazone-in-1-methyl-4-phenyl-1-2-3-6-tetrahydropyridine-and-6-hydroxydopamine-rodent-models-of-parkinsons-disease--
    [actif_langue] => 1
    [read] => 824
    [count_comments] => 0
    [id] => 401
    [categories] => Array
        (
            [45] => Array
                (
                    [id_prestablog_categorie] => 45
                    [title] => Maladie de Parkinson
                    [link_rewrite] => Maladie-de-Parkinson
                )

            [12] => Array
                (
                    [id_prestablog_categorie] => 12
                    [title] => Neurodégénérescence
                    [link_rewrite] => Neurodegenerescence
                )

            [2] => Array
                (
                    [id_prestablog_categorie] => 2
                    [title] => Publications
                    [link_rewrite] => publications
                )

        )

    [authors] => 
    [paragraph_crop] => Differential susceptibility to the PPAR-_ agonist pioglitazone in [...]
    [link_for_unique] => 1
    [products_liaison] => Array
        (
            [48] => Array
                (
                    [name] => Test d'agrippement
                    [description_short] => 
Une méthode simple pour quantifier objectivement la force musculaire des rats et souris et l'effet de drogues, toxines, maladies musculaires (ex: myopathie) et neurodégénératives. Cette mesure de force est souvent employée en association avec le test de coordination motrice ROTAROD: un sujet présentant une coordination normale montrera des résultats médiocres en cas de faible force musculaire. Un must pour vos recherches sur l'activité, la coordination et le contrôle musculaire: particulièrement utile pour vos études sur les maladies de Parkinson et Huntington.
Nouveautés GS4 - 2023: Écran couleur rétroéclairé (meilleure lisibilité), pédale de remise à zéro, durée de batterie optimisée, taille de mémoire augmentée à 500 valeurs, compteur d'animaux, port USB (transfert de données/charge)

                    [thumb] => 
                    [img_empty] => /var/www/vhosts/de3310.ispfr.net/preprod.bioseb.com/modules/prestablog/views/img/product_link_white.jpg
                    [image_presente] => 1
                    [link] => https://preprod.bioseb.com/fr/activite-systeme-moteur-coordination/48-grip-strength-test.html
                )

        )

)
1