Publications

Dernière publication 30/05/2001

Assessment of neurotoxicity following repeated cremophor and ethanol injection

As the mixture cremophor/ethanol is known to have side-effects affecting the peripheral nervous system, we have assessed its behavioural and...

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    [title] => Assessment of neurotoxicity following repeated cremophor  and  ethanol injection
    [paragraph] => Assessment of neurotoxicity following repeated cremophor / ethanol injections in rats.
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Authors
N. Authier, J.-P. Gillet, J. Fialip, A. Eschalier, F. Coudore.

 Lab
Université d’ Auvergne (INSERM EMI 9904), Laboratoire de Toxicologie, Equipe NeuroPsychoPharmacologie, Clermont-Ferrand, France.
Journal
Neurotoxicity Research
Abstract
As the mixture cremophor/ethanol is known to have side-effects affecting the peripheral nervous system, we have assessed its behavioural and morphological neurotoxicity after repeated intraperitoneal injections in male Sprague Dawley rats. Clinical status of the animals was good throughout the experiment and no motor deficits were observed. Nevertheless, sensory testing demonstrated an hyperalgesia and an allodynia to mechanical stimuli, associated to peripheral axon degeneration.
BIOSEB Instruments Used
Grip strength test (BIO-GS3)
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Une méthode simple pour quantifier objectivement la force musculaire des rats et souris et l'effet de drogues, toxines, maladies musculaires (ex: myopathie) et neurodégénératives. Cette mesure de force est souvent employée en association avec le test de coordination motrice ROTAROD: un sujet présentant une coordination normale montrera des résultats médiocres en cas de faible force musculaire. Un must pour vos recherches sur l'activité, la coordination et le contrôle musculaire: particulièrement utile pour vos études sur les maladies de Parkinson et Huntington.
Nouveautés GS4 - 2023: Écran couleur rétroéclairé (meilleure lisibilité), pédale de remise à zéro, durée de batterie optimisée, taille de mémoire augmentée à 500 valeurs, compteur d'animaux, port USB (transfert de données/charge)

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