Publications

Dernière publication 01/04/2008

Cutaneous Amitriptyline in Human Volunteers- Differential Effects on the Compone

Background : Amitriptyline is effective in relieving neuropathic pain. Its site of action is thought to be supraspinal and spinal, but a...

Array
(
    [id_prestablog_news] => 1368
    [id_shop] => 1
    [date] => 2008-04-01 00:00:00
    [date_modification] => 2024-02-09 14:15:12
    [langues] => ["1","2"]
    [actif] => 1
    [slide] => 0
    [url_redirect] => 
    [average_rating] => 
    [number_rating] => 
    [author_id] => 1
    [featured] => 0
    [prim_key] => 2935
    [id_lang] => 2
    [title] => Cutaneous Amitriptyline in Human Volunteers- Differential Effects on the Compone
    [paragraph] => Cutaneous Amitriptyline in Human Volunteers- Differential Effects on the Components of Sensory Information
    [content] => 
Authors
C Duale, J Daveau, JM Cardot et al

 Lab
Centre Hospitalier Universitaire (CHU) Clermont-Ferrand, Service d'Anesthesie-Reanimation, Hopital Gabriel-Montpied, France
Journal
Anesthesiology
Abstract
Background: Amitriptyline is effective in relieving neuropathic pain. Its site of action is thought to be supraspinal and spinal, but a peripheral effect on fibers is also suggested/
Methods This double-blind study examined the effects of transcutaneous amitriptyline diluted in hydroalcoholic solution in healthy young male volunteers. Six treatments were randomly applied on different areas of the skin of the back: amitriptyline at 0 (vehicle), 25, 50, and 100 mm; saline (control); and lidocaine-prilocaine cream as a positive control. Up to 24 h after application, mechanical thresholds for touch and nociception, and thermal thresholds for cold, warm, and heat sensation were recorded for each area. Blood samples were collected to assess plasma levels of amitriptyline. A late recording of the tactile thresholds was performed 1 and 3 weeks after the treatment session.
Results The thresholds for all sensations did not differ between the vehicle and saline. Lidocaine-prilocaine cream displayed a short-lasting anesthetic effect for all sensations, although this was not significant for warm sensation. Amitriptyline, at the three concentrations studied, induced a mild and short-lasting increase of the tactile and mechanical nociceptive thresholds. It significantly decreased cold thresholds (down to 21.8 degrees C, P = 0.01 vs. 27.5 degrees C for control) and heat thresholds (down to 40.1 degrees C, P = 0.004 vs. 43.4 degrees C for control). These two effects were no longer significant after the fourth hour of observation. Amitriptyline did not change warm thresholds. There was no apparent systemic absorption effect of the drug.
Conclusion It is hypothesized that amitriptyline has a differential effect on different fiber structures.
BIOSEB Instruments Used
Electronic Von Frey 4 (BIO-EVF4),Electronic Von Frey 5 with embedded camera (BIO-EVF5)
    [meta_description] => 
    [meta_keywords] => https://pubs.asahq.org/anesthesiology/article/108/4/714/8295/Cutaneous-Amitriptyline-in-Human
    [meta_title] => 
    [link_rewrite] => cutaneous-amitriptyline-in-human-volunteers--differential-effects-on-the-components-of-sensory-information
    [actif_langue] => 1
    [read] => 1037
    [count_comments] => 0
    [id] => 1368
    [categories] => Array
        (
            [29] => Array
                (
                    [id_prestablog_categorie] => 29
                    [title] => Douleurs neuropathiques
                    [link_rewrite] => Douleurs-neuropathiques
                )

            [2] => Array
                (
                    [id_prestablog_categorie] => 2
                    [title] => Publications
                    [link_rewrite] => publications
                )

        )

    [authors] => 
    [paragraph_crop] => Cutaneous Amitriptyline in Human Volunteers- Differential Effects on the Components of Sensory [...]
    [link_for_unique] => 1
    [products_liaison] => Array
        (
            [1859] => Array
                (
                    [name] => Von Frey Électronique - Sans Fil
                    [description_short] => 
Une solution rapide pour déterminer le seuil de sensibilité à la douleur mécanique chez les rongeurs (rats et souris). Maintenant en version sans-fil, pour être libéré des câbles!

Cet instrument électronique précis et simple d'utilisation est le test de référence pour vos recherches en analgésie, nociception, neuropathies et douleurs post-opératoires

                    [thumb] => 
                    [img_empty] => /var/www/vhosts/de3310.ispfr.net/preprod.bioseb.com/modules/prestablog/views/img/product_link_white.jpg
                    [image_presente] => 1
                    [link] => https://preprod.bioseb.com/fr/douleur-allodyniehyperalgesie-mecanique/1859-electronic-von-frey-4.html
                )

            [1860] => Array
                (
                    [name] => Von Frey Électronique 5 avec caméra intégrée
                    [description_short] => 

En tant que version électronique du classique esthésiomètre à filaments de Von Frey, la dernière évolution de l’instrument électronique Von Frey de Bioseb, conçu pour déterminer le seuil de sensibilité mécanique chez les rongeurs (rats et souris) par stimulation sous la patte, est un outil indispensable pour vos recherches sur l’hyperalgésie et l’allodynie. En mesurant et en enregistrant la force à laquelle l’animal présente un réflexe de retrait de la patte, il est possible d’étudier les pathologies liées à la réponse sensorielle ainsi qu’à l’hyper- ou l’hypoesthésie.
L'EVF5 intègre une caméra embarquée au niveau de la zone de stimulation et fonctionne avec un nouveau logiciel dédié révolutionnaire

                    [thumb] => 
                    [img_empty] => /var/www/vhosts/de3310.ispfr.net/preprod.bioseb.com/modules/prestablog/views/img/product_link_white.jpg
                    [image_presente] => 1
                    [link] => https://preprod.bioseb.com/fr/douleur-allodyniehyperalgesie-mecanique/1860-electronic-von-frey-5-with-embedded-camera.html
                )

        )

)
1