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Dernière publication 30/11/2012

Long-Term Changes in Trigeminal Ganglionic and Thalamic Neuronal Activities foll

The transection of the inferior alveolar nerve (IANx) produces allodynia in the whisker pad (V2 division) of rats. Ectopic discharges from injured...

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    [title] => Long-Term Changes in Trigeminal Ganglionic and Thalamic Neuronal Activities foll
    [paragraph] => Long-Term Changes in Trigeminal Ganglionic and Thalamic Neuronal Activities following Inferior Alveolar Nerve Transection in Behaving Rats 
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Authors
W.-T. Tseng, M.-L. Tsai., K. Iwata., C.-T. Yen.

 Lab
National Taiwan University, Taipei, Taiwan.
Journal
The Journal of Neuroscience
Abstract
The transection of the inferior alveolar nerve (IANx) produces allodynia in the whisker pad (V2 division) of rats. Ectopic discharges from injured trigeminal ganglion (TG) neurons and thalamocortical reorganization are possible contributors to the sensitization of uninjured V2 primary and CNS neurons. To test which factor is more important, TG and ventroposterior medial nucleus (VPM) neurons were longitudinally followed before, during, and after IANx for up to 80 d. Spontaneous discharges and mechanical stimulation-evoked responses were recorded in conscious and in anesthetized states. Results show (1) a sequential increase in spontaneous activities, first in the injured TG neurons of the IAN (2–30 d), followed by uninjured V2 ganglion neurons (6–30 d), and then VPM V2 neurons (7–30 d) after IANx; (2) ectopic discharges included burst and regular firing patterns in the IAN and V2 branches of the TG neurons; and (3) the receptive field expanded, the modality shifted, and long-lasting after-discharges occurred only in VPM V2 neurons. All of these changes appeared in the late or maintenance phase (7–30 d) and disappeared during the recovery phase (40–60 d). These observations suggest that ectopic barrages in the injured IAN contribute more to the development of sensitization, whereas the modality shift and evoked after-discharges in the VPM thalamic neurons contribute more to the maintenance phase of allodynia by redirecting tactile information to the cortex as nociceptive. 
BIOSEB Instruments Used
Rodent pincher - analgesia meter (BIO-RP-M)
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Un algomètre rapide et précis, basé sur une pince instrumentée: une alternative au test de Randall-Selitto. Ce nouvel algésimètre développé par Bioseb selon Luis-Delgado et al. (2005) permet des tests nociceptifs précis et la mesure du seuil de douleur mécanique sur pattes de rats ou de souris, avec une contrainte minimale. Maintenant en version sans-fil, pour être libéré des câbles!

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