Publications

Dernière publication 01/11/2008

CNS Disorders—Current Treatment Options and the Prospects for Advanced Therapies

The development of new pharmaceutical products has successfully addressed a multitude of disease states; however, new product development for...

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    [title] => CNS Disorders—Current Treatment Options and the Prospects for Advanced Therapies
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Authors
J. C. DiNunzio, R. O. WilliamsIII.

 Lab
The University of Texas at Austin, Division of Pharmaceutics, Austin, USA.
Journal
Drug Development and Industrial Pharmacy
Abstract
The development of new pharmaceutical products has successfully addressed a multitude of disease states; however, new product development for treating disorders of the central nervous system (CNS) has lagged behind other therapeutic areas. This is due to several factors including the complexity of the diseases and the lack of technologies for delivery through the blood–brain barrier (BBB). This article examines the current state of six major CNS disease states: depression, epilepsy, multiple sclerosis (MS), neurodegenerative diseases (specifically Alzheimer's disease [AD]), neuropathic pain, and schizophrenia. Discussion topics include analysis of the biological mechanisms underlying each disease, currently approved products, and available animal models for development of new therapeutic agents. Analysis of currently approved therapies shows that all products depend on the molecular properties of the drug or prodrug to penetrate the BBB. Novel technologies, capable of enhancing BBB permeation, are also discussed relative to improving CNS therapies for these disease states.
BIOSEB Instruments Used
Tail Suspension Test - Wireless (BIO-TST5)
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La version 5 du Test de Suspension Caudale de Bioseb, basée sur des capteurs de force ainsi que sur de l'acquisition vidéo, est la seule et unique solution totalement automatisée au monde pour effectuer un test de désespoir comportemental simple et objectif sur souris. Il s'agit d'une méthode rapide, fiable et sans douleur pour tester les effets psychotropes de drogues et substances comme les antidépresseurs et les sédatifs. Ce test classique et indolore pour la recherche sur l'anxiété et la dépression est désormais présenté avec un nouveau logiciel puissant et moderne, dans une version sans-fil BlueTooth.

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