Publications

Dernière publication 31/10/2005

The novel analgesic- F 13640- produces intra- and postoperative analgesia in a r

F 13640 is a newly discovered high-efficacy 5-HT1A receptor agonist that produces exceptional analgesia in animal models of tonic and chronic,...

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    [title] => The novel analgesic- F 13640- produces intra- and postoperative analgesia in a r
    [paragraph] => The novel analgesic, F 13640, produces intra- and postoperative analgesia in a rat model of surgical pain.
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Authors
I. Kiss, A.-D. Degryse, L. Bardin, I. A. Gomez de Segura, F. C. Colpaert et al.

 Lab
Klinik für Anästhesie, Intensivmedizin und Schmerztherapie, Alfried Krupp Krankenhaus, Essen, Germany ; Centre de Recherche Pierre Fabre, Castres, France ; Hospital Universitario La Paz, Department of Experimental Surgery, Madrid, Spain.
Journal
European Journal of Pharmacology
Abstract
F 13640 is a newly discovered high-efficacy 5-HT1A receptor agonist that produces exceptional analgesia in animal models of tonic and chronic, nociceptive and neuropathic pains by novel molecular and neuroadaptive mechanisms. Here we examined the effects of F 13640 and remifentanil (0.63 mg/kg with either compound) when injected i.p. either before or 15 min after rats underwent orthopedic surgery. Surgery consisted of the drilling of a hole in the calcaneus bone and of an incision of the skin, fascia and plantar muscle of one foot. During surgery, the concentration of volatile isoflurane was progressively incremented depending on the animal's response to surgical maneuvers. Other experiments examined the dose-dependent effects of F 13640 (0.04 to 0.63 mg/kg) on surgical pain as well as on the Minimum Alveolar Concentration of isoflurane. Both F 13640 and remifentanil markedly reduced the intra-operative isoflurane requirement. F 13640 also reduced measures of postoperative pain (i.e., paw elevation and flexion). With these postoperative measures, remifentanil produced short-lived analgesia followed by hyperalgesia. F 13640 significantly reduced both surgical pain and the isoflurane Minimum Alveolar Concentration from 0.16 mg/kg onward. F 13640 produced powerful intra- and postoperative analgesia in rats undergoing orthopedic surgery. Unlike the opioid, remifentanil, F 13640 caused no hyperalgesia with ongoing postoperative pain, and should remain effective with protracted postoperative use.
BIOSEB Instruments Used
Electronic Von Frey 4 (BIO-EVF4),Electronic Von Frey 5 with embedded camera (BIO-EVF5)
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Une solution rapide pour déterminer le seuil de sensibilité à la douleur mécanique chez les rongeurs (rats et souris). Maintenant en version sans-fil, pour être libéré des câbles!

Cet instrument électronique précis et simple d'utilisation est le test de référence pour vos recherches en analgésie, nociception, neuropathies et douleurs post-opératoires

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L'EVF5 intègre une caméra embarquée au niveau de la zone de stimulation et fonctionne avec un nouveau logiciel dédié révolutionnaire

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