Douleurs inflammatoires - page 2 - Publications Scientifiques

Dernière publication 04/10/2021

Inhibiting endocytosis in CGRP nociceptors attenuates inflammatory pain-like beh

The advantage of locally applied anesthetics is that they are not associated with the many adverse effects, including addiction liability, of...

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    [title] => Inhibiting endocytosis in CGRP nociceptors attenuates inflammatory pain-like beh
    [paragraph] => Inhibiting endocytosis in CGRP nociceptors attenuates inflammatory pain-like behavior
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Authors
R Powell, VA Young, KD Pryce, et al

 Lab
University at Buffalo - The State University of New York, Buffalo, NY, USA
Journal
Nature Communications
Abstract
The advantage of locally applied anesthetics is that they are not associated with the many adverse effects, including addiction liability, of systemically administered analgesics. This therapeutic approach has two inherent pitfalls: specificity and a short duration of action. Here, we identified nociceptor endocytosis as a promising target for local, specific, and long-lasting treatment of inflammatory pain. We observed preferential expression of AP2α2, an α-subunit isoform of the AP2 complex, within CGRP+/IB4- nociceptors in rodents and in CGRP+ dorsal root ganglion neurons from a human donor. We utilized genetic and pharmacological approaches to inhibit nociceptor endocytosis demonstrating its role in the development and maintenance of acute and chronic inflammatory pain. One-time injection of an AP2 inhibitor peptide significantly reduced acute and chronic pain-like behaviors and provided prolonged analgesia. We evidenced sexually dimorphic recovery responses to this pharmacological approach highlighting the importance of sex differences in pain development and response to analgesics.
BIOSEB Instruments Used
Dynamic Weight Bearing 2.0 (BIO-DWB-DUAL)
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Un système permettant l'analyse de la posture des animaux par la répartition du poids sur chacune des 4 pattes. Le DWB est un test unique dans l'étude de nombreux modèles de douleurs, principalement non évoquée , neuropathique ou encore inflammatoire ainsi que pour les études sur l'osthéoarthrite et divers affections du SNC. 

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