Domaines de recherche divers - page 18 - Publications Scientifiques

Dernière publication 29/08/2013

The homeodomain factor Gbx1 is required for locomotion and cell specification in

Dorsal horn neurons in the spinal cord integrate and relay sensory information to higher brain centers. These neurons are organized in specific...

Array
(
    [id_prestablog_news] => 535
    [id_shop] => 1
    [date] => 2013-08-29 00:00:00
    [date_modification] => 2024-02-09 14:15:11
    [langues] => ["1","2"]
    [actif] => 1
    [slide] => 0
    [url_redirect] => 
    [average_rating] => 
    [number_rating] => 
    [author_id] => 1
    [featured] => 0
    [prim_key] => 1046
    [id_lang] => 2
    [title] => The homeodomain factor Gbx1 is required for locomotion and cell specification in
    [paragraph] => The homeodomain factor Gbx1 is required for locomotion and cell specification in the dorsal spinal cord
    [content] => 
Authors
H. Meziane​, V. Fraulob, F. Riet, W. Krezel, M. Selloum et al.

 Lab
Institut Clinique de la Souris, Université de Strasbourg, Illkirch Cedex, France
Journal
PeerJ
Abstract
Dorsal horn neurons in the spinal cord integrate and relay sensory information to higher brain centers. These neurons are organized in specific laminae and different transcription factors are involved in their specification. The murine homeodomain Gbx1 protein is expressed in the mantle zone of the spinal cord at E12.5-13.5, correlating with the appearance of a discernable dorsal horn around E14 and eventually defining a narrow layer in the dorsal horn around perinatal stages. At postnatal stages, Gbx1 identifies a specific subpopulation of GABAergic neurons in the dorsal spinal cord. We have generated a loss of function mutation for Gbx1 and analyzed its consequences during spinal cord development. Gbx1−/− mice are viable and can reproduce as homozygous  mutants. However, the adult mutant mice display an altered gait during forward movement that specifically affects the hindlimbs. This abnormal gait was evaluated by a series of behavioral tests, indicating that locomotion is impaired, but not muscle strength or motor coordination. Molecular analysis showed that the development of the dorsal horn is not profoundly affected in Gbx1−/− mutant mice. However, analysis of terminal neuronal differentiation revealed that the proportion of GABAergic inhibitory interneurons in the superficial dorsal horn is diminished. Our study unveiled a role for Gbx1 in specifying a subset of GABAergic neurons in the dorsal horn of the spinal cord involved in the control of posterior limb movement.
BIOSEB Instruments Used
Aron Test or Four Plates Test (LE830),Rotarod (BX-ROD)
    [meta_description] => 
    [meta_keywords] => https://peerj.com/articles/142/
    [meta_title] => 
    [link_rewrite] => the-homeodomain-factor-gbx1-is-required-for-locomotion-and-cell-specification-in-the-dorsal-spinal-cord
    [actif_langue] => 1
    [read] => 892
    [count_comments] => 0
    [id] => 535
    [categories] => Array
        (
            [26] => Array
                (
                    [id_prestablog_categorie] => 26
                    [title] => Domaines de recherche divers
                    [link_rewrite] => Domaines-de-recherche-divers
                )

            [2] => Array
                (
                    [id_prestablog_categorie] => 2
                    [title] => Publications
                    [link_rewrite] => publications
                )

        )

    [authors] => 
    [paragraph_crop] => The homeodomain factor Gbx1 is required for locomotion and cell specification in the dorsal [...]
    [link_for_unique] => 1
    [products_liaison] => Array
        (
            [588] => Array
                (
                    [name] => Test d'Aron ou 'Four Plates Test'
                    [description_short] => 
Le 'Four Plates Test' ou test d'Aron est une exclusivité Bioseb!
Un outil rapide pour l'évaluation de substances anxiolytiques putatives chez l'animal naïf. Un "must" pour l'étude de l'anxiété, le screening des drogues et le phénotypage.
                    [thumb] => 
                    [img_empty] => /var/www/vhosts/de3310.ispfr.net/preprod.bioseb.com/modules/prestablog/views/img/product_link_white.jpg
                    [image_presente] => 1
                    [link] => https://preprod.bioseb.com/fr/anxiete-depression/588-aron-test-or-four-plates-test.html
                )

            [1326] => Array
                (
                    [name] => Rotarod pour rats et souris
                    [description_short] => 
Le Rotarod offre une méthode facile pour le test de l'activité motrice chez les rongeurs (rats ou souris) - une solution idéale pour étudier les lésions du système nerveux central (SNC), les effets de différentes pathologies et substances pharmacologiques sur l'activité motrice, la résistance à la fatigue, etc. Désormais encore plus simple d'utilisation! La nouvelle interface utilisateur graphique et tactile permet une visualisation claire de la vitesse et des temps associés à chaque piste. Vous pouvez maintenant changer de mode, régler la vitesse et créer des protocoles directement depuis l'écran principal for une une plus grande flexibilité et un maximum de fonctionnalités.

                    [thumb] => 
                    [img_empty] => /var/www/vhosts/de3310.ispfr.net/preprod.bioseb.com/modules/prestablog/views/img/product_link_white.jpg
                    [image_presente] => 1
                    [link] => https://preprod.bioseb.com/fr/activite-systeme-moteur-coordination/1326-rotarod.html
                )

        )

)
1